English
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Publications

2017

  • Marston WA, Ennis WJ, Lantis JC 2nd, Kirsner RS, Galiano RD, Vanscheidt W, Eming SA, Malka M, Cargill DI, Dickerson JE JrSlade HBHP802-247 Study Group (2017). Baseline factors affecting closure of venous leg ulcers. J Vasc Surg Venous Lymphat Disord. 2017 Nov;5(6):829-835.e1. doi: 10.1016/j.jvsv.2017.06.017
  • Gutiérrez S, Wolke M, Plum G, Robinson N (2017). Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages. J Vis Exp. (128), e56514, doi:10.3791/56514
  • Nürnberg C, Kociok N, Brockmann C, Lischke T, Crespo-Garcia S, Reichhart N, Wolf S, Baumgrass R, Eming SA, Beer-Hammer S, Joussen AM (2017). Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells. Exp Eye Res. 2017 Oct 14. pii: S0014-4835(17)30458-X. doi: 10.1016/j.exer.2017.10.011. [Epub ahead of print]
  • Tain LS, Sehlke R, Jain C, Chokkalingam M, Nagaraj N, Essers P, Rassner M, Grönke S, Fröhlich J, Dieterich C, Mann M, Alic N, Beyer A,  Partridge L (2017). A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Mol Syst Biol. 13, 939
  • Augustin H, McGourty K, Allen MJ, Madem SK, Adcott J, Kerr F, Wong CT, Vincent A, Godenschwege T, Boucrot E, Partridge L (2017). Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol. 15, e2001655
  • Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT (2017). Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. FASEB J. 2017 Sep 6. pii: fj.201700309R. doi: 10.1096/fj.201700309R. [Epub ahead of print]
  • Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne E, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM (2017). E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and Tight Junction positioning. Nature Communications. Accepted
  • Wieland D, Brachvogel B, Hornig-Do HT, Neuhaus J, Holzer T, Tobin D, Niessen CM, Wiesner R, Baris O (2017). Imbalance of mitochondrial respiratory chain complexes in the epidermis induces severe skin inflammation. J Invest Derm. Accepted
  • Koehler FC, Cornely OA, Wisplinghoff H, Chang DH, Richter A, Koehler P (2017). Candida reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine. Mycoses. 2017 Sep 5. doi: 10.1111/myc.12696. [Epub ahead of print]
  • Pokrzywa W, Lorenz R, Hoppe T (2017). Chaperone-Directed Ubiquitylation Maintains Proteostasis At the Expense of Longevity. Worm. In press
  • Gorsky MK, Burnouf S, Sofola-Adesakin O, Dols J, Augustin H, Weigelt CM, Grönke S, Partridge L (2017). Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity. Sci Rep7, 9984
  • Lessel D, Wu D, Trujillo C, Ramezani TLessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz PSpeit G, Högel J, Thiele H, Nürnberg G, Nürnberg P, Hammerschmidt M, Zhu Y, Tong DR, Katz C, Martin GM, Oshima J, Prives CKubisch C (2017). Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest. 2017 Oct 2;127(10):3598-3608. doi: 10.1172/JCI92171. Epub 2017 Aug 28
  • Li P, Stumpf M, Müller R, Eichinger L, Glöckner G, Noegel AA (2017). The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation. Sci Rep. Aug 22;7(1):9157. doi: 10.1038/s41598-017-08837-7
  • Jahn HM, Bergami M (2017). Critical periods regulating the circuit integration of adult-born hippocampal neurons. Cell Tissue Res. 2017 Aug 22. doi: 10.1007/s00441-017-2677-x. [Epub ahead of print]
  • Smith P, Willemsen D, Popkes M, Metge F, Gandiwa E, Reichard M, Valenzano DR (2017). Regulation of Life Span by the Gut Microbiota in The Short-Lived African Turquoise Killifish. Elife. Aug 22;6. doi: 10.775/eLife.27014
  • Schulz J, Avci D, Queisser MA, Gutschmidt A, Dreher LS, Fenech EJ, Volkmar N, Hayashi Y, Hoppe T, Christianson JC (2017). Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). J Cell Sci. In press
  • Bustos V, Partridge L (2017). Good Ol' Fat: Links between Lipid Signaling and Longevity. Trends. Biochem Sci. In press
  • Januschke J, Wodarz A (2017). Notch Signaling: Where Is the Action? Curr Biol. 27, R760-R762
  • Kuhlmann N, Chollet C, Baldus L, Neundorf I, Lammers M (2017). Development of Substrate-Derived Sirtuin Inhibitors with Potential Anticancer Activity. ChemMedChem. Doi: 10.1002/cmdc.201700414. In press
  • Hos D, Bukowiecki A, Horstmann J, Bock F, Bucher F, Heindl LM, Siebelmann S, Steven P, Dana R, Eming SA, Cursiefen C (2017). Transient Ingrowth of Lymphatic Vessels into the Physiologically Avascular Cornea Regulates Corneal Edema and Transparency. Sci Rep. 2017 Aug 3;7(1):7227. doi: 10.1038/s41598-017-07806-4
  • Berner R, Bogner JR, Cornely OA, de With K, Herold S, Kern WV, Lemmen S, Pletz MW, Ruf B, Salzberger B, Stellbrink HJ, Suttorp N, Ullmann AJ, Fatkenheuer G, Jung N, Cornely OA, Leguay T, Maertens J, Vehreschild M, Anagnostopoulos A, Castagnola C, Verga L, Rieger C, Kondakci M, Harter G, Duarte RF, Allione B, Cordonnier C, Heussel CP, Morrissey CO, Agrawal SG, Donnelly JP, Bresnik M, Hawkins MJ, Garner W, Gokbuget N (2017). Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia. Infection
  • Cornely OA,  Leguay T, Maertens J,  Vehreschild MJGT,  Anagnostopoulos A, Castagnola C,  Verga L, Rieger C, Kondakci M,  Härter G,  Duarte RF,  Allione B, Cordonnier C,  Heussel CP, Morrissey CO, Agrawal SG, Donnelly JP,  Bresnik M, Hawkins MJ, Garner W, Gökbuget N (2017). Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia. J Antimicrob Chemother. doi:10.1093/jac/dkx133 
  • Paeger L, Pippow A, Hess S, Paehler M, Klein AC, Husch A, Pouzat C, Brüning JCKloppenburg P (2017). Energy imbalance alters Ca2+ handling and excitability of POMC neurons. Elife. 2017 Aug 1;6. pii: e25641. doi: 10.7554/eLife.25641. PMID: 28762947
  • Sartelli M, Labricciosa FM, Barbadoro P, Pagani L, Ansaloni L, Brink AJ, Carlet J, Khanna A, Chichom-Mefire A, Coccolini F, Di Saverio S, May AK, Viale P, Watkins RR, Scudeller L, Abbo LM, Abu-Zidan FM, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Alis H, Alves C, Araujo da Silva AR, Augustin G, Bala M, Barie PS, Beltran MA, Bhangu A, Bouchra B, Brecher SM, Cainzos MA, Camacho-Ortiz A, Catani M, Chandy SJ, Jusoh AC, Cherry-Bukowiec JR, Chiara O, Colak E, Cornely OA, Cui Y, Demetrashvili Z, De Simone B, De Waele JJ, Dhingra S, Di Marzo F, Dogjani A, Dorj G, Dortet L, Duane TM, Elmangory MM, Enani MA, Ferrada P, Esteban Foianini J, Gachabayov M, Gandhi C, Ghnnam WM, Giamarellou H, Gkiokas G, Gomi H, Goranovic T, Griffiths EA, Guerra Gronerth RI, Haidamus Monteiro JC, Hardcastle TC, Hecker A, Hodonou AM, Ioannidis O, Isik A, Iskandar KA, Kafil HS, Kanj SS, Kaplan LJ, Kapoor G, Karamarkovic AR, Kenig J, Kerschaever I, Khamis F, Khokha V, Kiguba R, Kim HB, Ko WC, Koike K, Kozlovska I, Kumar A, Lagunes L, Latifi R, Lee JG, Lee YR, Leppaniemi A, Li Y, Liang SY, Lowman W, Machain GM, Maegele M, Major P, Malama S, Manzano-Nunez R, Marinis A, Martinez Casas I, Marwah S, Maseda E, McFarlane ME, Memish Z, Mertz D, Mesina C, Mishra SK, Moore EE, Munyika A, Mylonakis E, Napolitano L, Negoi I, Nestorovic MD, Nicolau DP, Omari AH, Ordonez CA, Paiva JA, Pant ND, Parreira JG, Pedziwiatr M, Pereira BM, Ponce-de-Leon A, Poulakou G, Preller J, Pulcini C, Pupelis G, Quiodettis M, Rawson TM, Reis T, Rems M, Rizoli S, Roberts J, Pereira NR, Rodriguez-Bano J, Sakakushev B, Sanders J, Santos N, Sato N, Sawyer RG, Scarpelini S, Scoccia L, Shafiq N, Shelat V, Sifri CD, Siribumrungwong B, Soreide K, Soto R, de Souza HP, Talving P, Trung NT, Tessier JM, Tumbarello M, Ulrych J, Uranues S, Van Goor H, Vereczkei A, Wagenlehner F, Xiao Y, Yuan KC, Wechsler-Fordos A, Zahar JR, Zakrison TL, Zuckerbraun B, Zuidema WP, Catena F (2017). The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey. World Journal of Emergency Surgery : WJES. 2017;12:34
  • Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, Tiganis T (2017). A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. Cell Metab. 2017 Aug 1;26(2):375-393.e7. doi: 10.1016/j.cmet.2017.07.013
  • Paeger L, Pippow A, Hess S, Paehler M, Klein AC, Husch A, Pouzat C, Brüning JC, Kloppenburg P (2017). Energy imbalance alters Ca2+ handling and excitability of POMC neurons. Elife. 2017 Aug 1;6. pii: e25641. doi: 10.7554/eLife.25641
  • Seidel D, Duran Graeff LA, Vehreschild MJGT, Wisplinghoff H, Ziegler M, Vehreschild J, Liss B, Hamprecht A, Köhler P, Racil Z, Klimko N, Sheppard DC, Herbrecht R, Chowdhary A, Cornely OA (2017). FungiScope -Global Emerging Fungal Infection Registry. Mycoses. 2017;60(8):508-16
  • Wilson DM3rd, Rieckher M, Williams AB, Schumacher B (2017). Systematic analysis of DNA crosslink repair pathways during development and aging in C. elegansNucleic Acids Res. 2017. doi:10.1093/nar/gkx660 
  • Walther G, Stasch S, Kaerger K, Hamprecht A, Roth M, Cornely OA, Geerling G, Mackenzie CR, Kurzai O, von Lilienfeld-Toal M (2017). Fusarium Keratitis in Germany. J Clin Microbiol. 2017 Jul 26. pii: JCM.00649-17. doi: 10.1128/JCM.00649-17. [Epub ahead of print]
  • Franke M, Baeßler B, Vechtel J, Dafinger C, Höhne M, Borgal L, Göbel H, Koerber F, Maintz D, Benzing T, Schermer B, Persigehl T (2017). Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease. Kidney Int. 2017 Jul 26. pii: S0085-2538(17)30394-0. doi: 10.1016/j.kint.2017.05.024. [Epub ahead of print]
  • Kevei É, Pokrzywa W, Hoppe T (2017). Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis. FEBS Lett. In press
  • Cremaschi L, von Versen R, Benzing T, Wiesener M, Zink N, Milkovich G, Paivanas T, Gallagher M, Thaiss F (2017). Induction therapy with rabbit antithymocyte globulin versus basiliximab after kidney transplantation: a health economic analysis from a German perspective. Transpl Int. 2017 Oct;30(10):1011-1019. doi: 10.1111/tri.12991. Epub 2017 Jul 24
  • Rinschen MM, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T (2017). N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton. J Am Soc Nephrol. 2017 Oct;28(10):2867-2878. doi: 10.1681/ASN.2016101119. Epub 2017 Jul 19
  • Szczepanowska K, Trifunovic A (2017). Origins of mtDNA mutations in ageing. Essays Biochem. 2017 Jul 11;61(3):325-337. doi: 10.1042/EBC20160090. Print 2017 Jul 15. Review
  • Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B. The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. EMBO Rep. 2017 Sep;18(9):1521-1535. doi: 10.15252/embr.201643846. Epub 2017 Jul 14
  • Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W (2017). Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila. eLife. 6. 2017 Jul 12;6. pii: e24662. doi: 10.7554/eLife.24662. [Epub ahead of print]
  • Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A (2017). The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metab. 2017 Jul 5;26(1):198-211.e5. doi: 10.1016/j.cmet.2017.06.015
  • Theurich S, Tsaousidou E, Hanssen R, Lempradl AM, Mauer J, Timper K, Schilbach K, Folz-Donahue K, Heilinger C, Sexl V, Pospisilik JA, Wunderlich FT, Brüning JC (2017). IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis. Cell Metab. 2017 Jul 5;26(1):171-184.e6. doi: 10.1016/j.cmet.2017.05.018
  • Cornely OA, Mellinghoff SC (2017). Fever in Cancer Patients. Dtsch Med Wochenschr. 2017;142(13):961-8 
  • Göbel J, Motori E, Bergami M (2017). Spatiotemporal control of mitochondrial network dynamics in astroglial cells. Biochem Biophys Res Commun. 2017 Jul 1. pii: S0006-291X(17)31322-0. doi: 10.1016/j.bbrc.2017.06.191. [Epub ahead of print]
  • Theisen BE, Rumyantseva A, Cohen JS, Alcaraz WA, Shinde DN, Tang S, Srivastava S, Pevsner J, Trifunovic A, Fatemi A (2017). Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. Am J Med Genet A. 2017 Sep;173(9):2505-2510. doi: 10.1002/ajmg.a.38339. Epub 2017 Jun 26
  • Paeger L, Karakasilioti I, Altmüller J, Frommolt P, Brüning JKloppenburg P (2017). Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. Elife. 2017 Jun 20;6. pii: e25770. doi: 10.7554/eLife.25770. PMID: 28632132
  • Ziehm M, Kaur S, Ivanov DK, Ballester PJ, Marcus D, Partridge L, Thornton JM (2017). Drug repurposing for aging research using model organisms. Aging Cell. In Press. 2017 Jun 16. doi: 10.1111/acel.12626. [Epub ahead of print]
  • Bukowiecki A, Hos D, Cursiefen C, Eming SA (2017). Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities. Int J Mol Sci. 2017 Jun 12;18(6). pii: E1257. doi: 10.3390/ijms18061257
  • Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim HJ, Kloppenburg P, Liss B, Striessnig J (2017). Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease. J Neurosci. 2017 Jul 12;37(28):6761-6777. doi: 10.1523/JNEUROSCI.2946-16.2017. Epub 2017 Jun 7. PMID: 28592699
  • Timper K, Brüning JC (2017). Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Dis Model Mech. 2017 Jun 1;10(6):679-689. doi: 10.1242/dmm.026609
  • Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Brüning JC, Cooney G, Neely G, Herzog H (2017). Insulin controls food intake and energy balance via NPY neurons. Mol Metab. 2017 Apr 12;6(6):574-584. doi: 10.1016/j.molmet.2017.03.013. eCollection 2017 Jun
  • Franko A, Kunze A, Böse M, von Kleist-Retzow JC, Paulsson M, Hartmann U, Wiesner RJ (2017). Impaired insulin signaling is associated with hepatic mitochondrial dysfunction in IR+/--IRS-1+/- double heterozygous (IR-IRS1dh) mice. Int J Mol Sci. In press
  • Stumpf M, Müller R, Gaßen B, Wehrstedt R, Fey P, Karow MA, Eichinger L, Glöckner G, Noegel AA (2017). A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium. Dis Model Mech. Jul 1;10(7):897-907. doi: 10.1242/dmm.029280
  • Zhao Y, Gilliat AF, Ziehm M, Turmaine M, Wang H, Ezcurra M, Yang C, Phillips G, McBay D, Zhang WB, Partridge L, Pincus Z, Gems D (2017). Two forms of death in ageing Caenorhabditis elegans. Nat Commun. 8, 15458
  • Augustin H, McGourty K, Steinert JR, Cocheme HM, Adcott J, Cabecinha M, Vincent A, Halff EF, Kittler JT, Boucrot E, Partridge L (2017). Myostatin-like proteins regulate synaptic function and neuronal morphology. Development. In Press
  • Bonfiglio JJ, Colby T, Matic I (2017). Mass spectrometry for serine ADP-ribosylation? Think o-glycosylation! Nucleic Acids Res. 2017 May 18. doi: 10.1093/nar/gkx446. [Epub ahead of print]
  • Bartram MP, Mishra T, Reintjes N, Fabretti F, Gharbi H, Adam AC, Göbel H, Franke M, Schermer B, Haneder S, Benzing T, Beck BB, Müller RU (2017). Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer. BMC Med Genet. 2017 May 12;18(1):53. doi: 10.1186/s12881-017-0416-5
  • Cornely OA, Lass-Florl C (2017). Improving outcome of fungal diseases - Guiding experts and patients towards excellence. Mycoses. 2017;60(7):420-5
  • Schommers P, Thurau A, Bultmann-Mellin I, Guschlbauer M, Klatt AR, Rozman J, Klingenspor M, Hrabe de Angelis M, Alber J, Gründemann D, Sterner-Kock A, Wiesner RJ (2017). Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state. Mol Metab. In press
  • Ruud J, Steculorum SM, Brüning JC (2017). Neuronal control of peripheral insulin sensitivity and glucose metabolism. Nat Commun. 2017 May 4;8:15259. doi: 10.1038/ncomms15259
  • Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC (2017).Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance. Nat Commun. 2017 May 3;8:14803. doi: 10.1038/ncomms14803
  • Rieckher M, Bujarrabal A, Doll MA, Soltanmohammadi N, Schumacher B (2017). A simple answer to complex questions: C. elegans as an experimental model for examining the DNA damageresponse and disease genes. J Cell Physiol. 2017 May 2. doi: 10.1002/jcp.25979. [Epub ahead of print]
  • Lucas T, Schäfer F, Müller P, Eming SA, Heckel A, Dimmeler S (2017). Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice. Nature Communications. In press 
  • Eming SA, Wynn TA, Martin P (2017). Inflammation and Metabolism in Tissue Repair and Regeneration. Science. In press
  • Garinis GA, Schwer B, Schumacher B (2017). Editorial: DNA damage & immunity. Mech Ageing Dev. 2017 Apr 23. pii: S0047-6374(17)30097-0. doi: 10.1016/j.mad.2017.04.006. [Epub ahead of print]
  • Mizielinska S, Ridler CE, Balendra R, Thoeng A, Woodling NS, Grässer FA, Plagnol V, Lashley T, Partridge L, Isaacs AM (2017). Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathol Commun. 5, 29
  • Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B (2017). YAP-mediated mechanotransduction determines the podocyte's response to damage. Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165
  • Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC (2017). IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. Cell Rep. 2017 Apr 11;19(2):267-280. doi: 10.1016/j.celrep.2017.03.043
  • Ludewig AH, Gimond C, Judkins JC, Thornton S, Pulido DC, Micikas RJ, Döring F, Antebi A, Braendle C, Schroeder FC (2017). Larval crowding accelerates C. elegans development and reduces lifespan. PLoS Genet. 2017 Apr 10;13(4):e1006717. doi: 10.1371/journal.pgen.1006717. eCollection 2017 Apr
  • Risslegger B, Zoran T, Lackner M, Aigner M, Sánchez- Reus F, Rezusta A, Chowdhary A, Jaber Taj-Aldeen S, Arendrup MC, Oliveri S, Kontoyiannis DP, Alastruey-Izquierdo A, Lagrou K, Cascio GL, Meis JF,  Buzina W, Farina C, Drogari-Apiranthitou M, Grancini A, Tortorano AM, Willinger B, Hamprecht A,  Johnson E, Klingspor L, Arsic-Arsenijevic V, Cornely OA, Meletiadis J, Prammer W, Tullio V,  Vehreschild JJ, Trovato L,  Lewis RE, Segal E, Rath PM, Hamal P, Rodriguez-Iglesias M, Roilides E, Arikan-Akdagli S,  Chakrabarti A, Colombo AL, Fernández MS, Martin-Gomez MT, Badali H, Petrikkos G, Klimko N, Heimann SM, Houbraken J, Uzun O, Edlinger M, de la Fuente S, Lass-Flörl C (2017). A Prospective International Aspergillus terreus Survey: An EFISG, ISHAM and ECMM Joint Study. Clinical Microbiology and Infection. doi: 10.1016/j.cmi.2017.04.012 
  • Cornely OA,  Leguay T, Maertens J,  Vehreschild MJGT,  Anagnostopoulos A, Castagnola C,  Verga L, Rieger C, Kondakci M,  Härter G,  Duarte RF,  Allione B, Cordonnier C,  Heussel CP, Morrissey CO, Agrawal SG, Donnelly JP,  Bresnik M, Hawkins MJ, Garner W, Gökbuget N (2017). Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia. J Antimicrob Chemother. doi:10.1093/jac/dkx133
  • Berger H, Wodarz A, Borchers A (2017). PTK7 Faces the Wnt in Development and Disease. Front Cell Dev Biol. 05 April 2017. DOI 10.3389/fcell.2017.00031    
  • Braune J, Weyer U, Hobusch C, Mauer J, Brüning JC, Bechmann I, Gericke M (2017). IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity. J Immunol. 2017 Feb 13. pii: 1600476. doi: 10.4049/jimmunol.1600476. Epub 2017 Feb 13
  • Drees C, Vahl JC, Bortoluzzi S, Heger KD, Fischer JC, Wunderlich FT, Peschel C, Schmidt-Supprian M (2017). Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets. J Immunol. 2017 Feb 10. pii: 1601732   
  • Durán Graeff L, Seidel D, Vehreschild MJ, Hamprecht A, Kindo A, Racil Z, Demeter J, De Hoog S, Aurbach U, Ziegler M, Wisplinghoff H, Cornely OA, FungiScope Group (2017). Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry. Mycoses. 2017 Feb 2. doi: 10.1111/myc.12595. Epub 2017 Feb 2
  • Gehlsen U, Braun T, Notara M, Krösser S, Steven P (2017). A semifluorinated alkane (F4H5) as novel carrier for cyclosporine A: a promising therapeutic and prophylactic option for topical treatment of dry eye. Graefes Arch Clin Exp Ophthalmol. 2017 Jan 14. doi: 10.1007/s00417-016-3572-y. Epub 2017 Jan 14
  • Herling M, Rengstl B, Scholtysik R, Hartmann S, Küppers R, Hansmann ML, Diebner H, Roeder I, Abken H, Newrzela S, Kirberg J (2017). Concepts in mature T-cell lymphomas - highlights from an international joint symposium on T-cell immunology and oncology. Leuk Lymphoma. 2017 Apr;58(4):788-796
  • Kennedy BK, Partridge L (2017). 2nd interventions in aging conference. Aging. 9, 1090-1095
  • Osae AE, Gehlsen U, Horstmann J, Siebelmann S, Stern ME, Kumah DB, Steven P (2017). Epidemiology of dry eye disease in Africa: The sparse information, gaps and opportunities. Ocul Surf. 2017 Jan 5. pii: S1542-0124(16)30069-6. doi: 10.1016/j.jtos.2017.01.001. [Epub ahead of print]. Review
  • Sukumaran SK, Stumpf M, Salamon S, Ahmad I, Bhattacharya K, Fischer S, Müller R, Altmüller J, Budde B, Thiele H, Tariq M, Malik NA, Nürnberg P, Baig SM, Hussain MS, Noegel AA (2017). CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Mol Genet Genom. doi: 10.1007/s00438-016-1277-x
  • Tatsuta T, Langer T (2017). Intramitochondrial phospholipid trafficking. Biochim Biophys Acta. 1862, 81-89. doi: 10.1016/j.bbalip.2016.08.006
  • Ebner K, Dafinger C, Ortiz-Bruechle N, Koerber F, Schermer B, Benzing T, Dötsch J, Zerres K, Weber LT, Beck BB, Liebau MC (2017). Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations. Pediatr Nephrol. 2017 Jul;32(7):1269-1273. doi: 10.1007/s00467-017-3648-x. Epub 2017 Mar 31
  • Moens TG, Partridge L, Isaacs AM (2017). Genetic models of C9orf72: what is toxic? Curr Opin Genet Dev. 44, 92-101
  • Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L (2017). Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biol. 18(1):56
  • Voskarides K, Stefanou C, Pieri M, Demosthenous P, Felekkis K, Arsali M, Athanasiou Y, Xydakis D, Stylianou K, Daphnis E, Goulielmos G, Loizou P, Savige J, Höhne M, Völker LA, Benzing T, Maxwell PH, Gale DP, Gorski M, Böger C, Kollerits B, Kronenberg F, Paulweber B, Zavros M, Pierides A, Deltas C (2017). A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population. PLoS One. 2017 Mar 23;12(3):e0174274. doi: 10.1371/journal.pone.0174274. eCollection 2017
  • Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V (2017). Non-canonical aging model systems and why we need them. EMBO J. DOI: 10.15252/embj.201796837    
  • Jerkeman M, Hallek M, Dreyling M, Thieblemont C, Kimby E, Staudt L (2017). Targeting of B-cell receptor signalling in B-cell malignancies. J Intern Med. 2017 Mar 14. doi: 10.1111/joim.12600. [Epub ahead of print]
  • Lehmann C, Berner R, Bogner JR, Cornely OA, de With K, Herold S, Kern WV, Lemmen S, Pletz MW,  Ruf B, Salzberger B, Stellbrink HJ, Suttorp N, Ullmann AJ, Fätkenheuer G, Jung N (2017). The “Choosing Wisely” initiative in infectious diseases. Infection. Springer Verlag. DOI 10.1007/s15010-017-0997-0. Epub 2017 March 13 
  • Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T (2017). The rhomboid protease PARL regulates apoptosis via proteolytic maturation of Smac/DIABLO in mitochondria. Nature Cell Biol. In press
  • Piper MDW, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L (2017). Matching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan. Cell Metab. 25, 610-621
  • Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI (2017). CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. doi: 10.1083/jcb.201607019
  • Bassetti M, Garnacho‐Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A,  Kett D, Leon C, Ostrosky‐Zeichner L, Sanguinetti M, Timsit JF, Richardson MD,  Shorr A, Cornely OA (2017). Intensive care medicine research agenda on invasive fungal infection in critically ill patients. Intensive Care Med. DOI 10.1007/s00134-017-4731-2 
  • Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cocheme HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L (2017). Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS Genet. 13, e1006593
  • Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Krönke M, Utermöhlen O, Gopalakrishnan J (2017).  Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.  Cell Stem Cell. S1934-5909
  • Cornely OA (2017). Isavuconazole: is there a need for a new antifungal? J Antimicrob Chemother. 2017;72(suppl_1):i2-i4
  • Holtick U, Herling M, Pflug N, Chakupurakal G, Leitzke S, Wolf D, Hallek M, Scheid C, Chemnitz JM (2017). Similar outcome after allogeneic stem cell transplantation with a modified FLAMSA conditioning protocol substituting 4 Gy TBI with treosulfan in an elderly population with high-risk AML. Ann Hematol. 2017 Mar;96(3):479-487. doi: 10.1007/s00277-016-2887-4
  • Stoffel W, Schmidt-Soltau I, Jenke B, Binczek E, Hammels I (2017). Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by tA Artificial Lipid Barrier. J Invest Dermatol. doi:10.1016/j.jid.2017.02.97
  • Cruz-Molina S, Respuela P, Tebartz C, Kolovos P, Nikolic M, Fueyo R, Van  Ljcken WFJ, Grosveld F, Frommolt P, Bazzi H, Rada-Iglesias A (2017). PRC2 facilitates the regulatory topology required for poised enhancer function during pluripotent stem cell differentiation. Cell Stem Cell. In press
  • Wiesmuller GA, Heinzow B, Aurbach U, Bergmann KC, Bufe A, Buzina W, Cornely OA, Engelhart S, Fischer G, Gabrio T, Heinz W, Herr CEW, Kleine-Tebbe J, Klimek L, Koberle M, Lichtnecker H, Lob-Corzilius T, Merget R, Mulleneisen N, Nowak D, Rabe U, Raulf M, Seidl HP, Steiss JO, Szewszyk R, Thomas P, Valtanen K, Hurrass J (2017). Abridged version of the AWMF guideline for the medical clinical diagnostics of indoor mould exposure: S2K Guideline of the German Society of Hygiene, Environmental Medicine and Preventive Medicine GHUP in collaboration with the German Association of Allergists AeDA, the German Society of Dermatology DDG, the German Society for Allergology and Clinical Immunology DGAKI, the German Society for Occupational and Environmental Medicine DGAUM, the German Society for Hospital Hygiene DGKH, the German Society for Pneumology and Respiratory Medicine DGP, the German Mycological Society DMykG, the Society for Pediatric Allergology and Environmental Medicine GPA, the German Federal Association of Pediatric Pneumology BAPP, the Austrian Society for Medical Mycology OGMM. Allergo Journal International. 2017;26(5):168-93
  • Coppe A, Andersson EI, Binatti A, Gasparini VR, Bortoluzzi S, Clemente M, Herling M, Maciejewski J, Mustjoki S, Bortoluzzi S (2017). Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach. Leukemia. 2017 Feb 7. doi: 10.1038/leu.2017.49. [Epub ahead of print]
  • Ahmad I, Baig SM, Abdulkareem AR, Hussain MS, Sur I, Toliat MR, Nürnberg G, Dalibor N, Moawia A, Waseem SS, Asif M, Nagra H, Sher M, Khan MMA, Hassan I, Rehman SU, Thiele H, Altmüller J, Noegel AA, Nürnberg P (2017). Genetic heterogeneity in Pakistani microcephaly families revisited. Clin Genet. Jul;92(1):62-68. doi: 10.1111/cge.12955
  • Steculorum SM, Timper K, Engström Ruud L, Evers N, Paeger L, Bremser S, Kloppenburg P, Brüning JC (2017). Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity. Cell Rep. 2017 Feb 14;18(7):1587-1597. doi: 10.1016/j.celrep.2017.01.047
  • Bagshaw E, Kuessner D, Posthumus J, Escrig C, Blackney M, Heimann SM, Cornely OA (2017). The cost of treating mucormycosis with isavuconazole compared with standard therapy in the UK. Future Microbiol. 2017 Feb 13. doi: 10.2217/fmb-2016-0231. [Epub ahead of print]
  • Ganesan R, Hos NJ, Gutierrez S, Fischer J, Stepek JM, Daglidu E, Krönke M, Robinson N (2017). Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLOS Pathog. doi:10.1371/journal.ppta.1006227. Epub 2017 Feb 13
  • Bonfiglio JJ, Fontana P, Zhang Q, Colby T, Gibbs-Seymour I, Atanassov I, Bartlett E, Zaja R, Ahel I, Matic I (2017). Serine ADP-Ribosylation depends on HPF1. Mol Cell. 2017 Mar 2;65(5):932-940.e6. doi: 10.1016/j.molcel.2017.01.003. Epub 2017 Feb 9 
  • Paeger L, Bardos V, Kloppenburg P (2017). Transient Voltage Activated K+ Currents in Central Antennal Lobe Neurons: Cell Type Specific Functional Properties. J Neurophysiol. 2017 Feb 8:jn.00685.2016. doi: 10.1152/jn.00685.2016. [Epub ahead of print]
  • Salzer HJ, Cornely OA (2017). Awareness of predictors of mortality may help improve outcome in chronic pulmonary aspergillosis. Eur Respir J. 2017 Feb 8;49(2). pii: 1602520. doi: 10.1183/13993003.02520-2016. No abstract available
  • Koehler S, Brähler S, Braun F, Hagmann H, Rinschen MM, Späth MR, Höhne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT (2017). Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes. Kidney Int. 2017 Feb 7. pii: S0085-2538(16)30745-1
  • Durán Graeff L, Seidel D, Vehreschild MJ, Hamprecht A, Kindo A, Racil Z, Demeter J, De Hoog S, Aurbach U, Ziegler M, Wisplinghoff H, Cornely OA, FungiScope Group (2017). Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry. Mycoses. 2017 Feb 2. doi: 10.1111/myc.12595. [Epub ahead of print]
  • Bujarrabal A, Schumacher B (2017). Tracking senescent cells: A new biomarker assay opens new avenues in senescence research. Mech Ageing Dev. 2017 Feb 1. pii: S0047-6374(16)30293-7. doi: 10.1016/j.mad.2017.01.009
  • Eckes B, Eming SA (2016). Tissue fibrosis: a pathomechanistically unresolved challenge and scary clinical problem. Exp Dermatol (in press)
  • Hassler A, Lieb A, Seidel D, Cesaro S, Greil J, Klimko N, Khostelidi S, Solopova G, Ogunc D, Durán Graeff L, Cornely OA, Vehreschild MJ, Lehrnbecher T (2017). Disseminated Fusariosis in Immunocompromised Children-Analysis of Recent Cases Identified in the Global Fungiscope Registry. Pediatr Infect Dis J. 2017 Feb;36(2):230-231. doi: 10.1097/INF.0000000000001396
  • Koehler P, Hamprecht A, Bader O, Bekeredjian-Ding I, Buchheidt D, Doelken G, Elias J, Haase G, Hahn-Ast C, Karthaus M, Kekulé A, Keller P, Kiehl M, Krause SW, Krämer C, Neumann S, Rohde H, La Rosée P, Ruhnke M, Schafhausen P, Schalk E, Schulz K, Schwartz S, Silling G, Staib P, Ullmann A, Vergoulidou M, Weber T, Cornely OA, Vehreschild MJ (2017). Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study. Int J Antimicrob Agents. 2017 Feb;49(2):218-223. doi: 10.1016/j.ijantimicag.2016.10.019
  • Mescher M, Jeong P, Knapp S, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S (2017). The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. J Exp Med. 2017 Jan 17. pii: jem.20160596. doi: 10.1084/jem.20160596. Epub 2017 Jan 17
  • Muck J, Kean S, Valenzano DR (2017). The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on ageing. Handbook of Models of Human Aging, 2nd Ed. In Press
  • Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B (2017). Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis. Am J Hum Genet. 2017 Feb 2;100(2):297-315. doi: 10.1016/j.ajhg.2017.01.005
  • Shimabukuro-Vornhagen A, García-Márquez M, Fischer RN, Iltgen-Breburda J, Fiedler A, Wennhold K, Rappl G, Abken H, Lehmann C, Herling M, Wolf D, Fätkenheuer G, Rubbert-Roth A, Hallek M, Theurich S, von Bergwelt-Baildon M (2017). Antigen-presenting human B cells are expanded in inflammatory conditions. J Leukoc Biol. 2017 Feb;101(2):577-587
  • Solano C, Slavin M, Shaul AJ, Marks DI, Cordonnier C, Cornely OA, Pagliuca A, Cragin L, Jarque I, Garcia-Vidal C, Sorensen S, Vanness DJ, Charbonneau C, Barrueta JA, Peral C, De Salas-Cansado M, Bow EJ (2017). Economic evaluation of azoles as primary prophylaxis for the prevention of invasive fungal infections in Spanish patients undergoing allogeneic haematopoietic stem cell transplant. Mycoses. 2017 Feb;60(2):79-88. doi: 10.1111/myc.1255
  • Loeffelholz von C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm M, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AF, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL (2017). The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. Hepatology. 2017 Jan 30
  • Yin G, Kistler S, George SD, Kuhlmann N, Garvey L, Huynh M, Bagni RK, Lammers M, Der CJ, Campbell SL (2017). A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation. J Biol Chem. 292, 4446-4456
  • Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kuhne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F(2017). mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. J Am Soc Nephrol. 28: 230–241 
  • Wilcox MH, Gerding DN, Poxton IR, Kelly C, Nathan R, Birch T, Cornely OA, Rahav G, Bouza E, Lee C, Jenkin G, Jensen W, Kim YS, Yoshida J,Gabryelski L, Pedley A, Eves K, Tipping R, Guris D, Kartsonis N, Dorr MB, MODIFY I and MODIFY II Investigators (2017). Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection. N Engl J Med. 2017 Jan 26;376(4):305-317. doi: 10.1056/NEJMoa1602615
  • Gruber R, Rainer G, Weiss A, Udvardi A, Thiele H, Eckl KM, Schupart R, Nürnberg P, Zschocke J, Schmuth M, Volc-Platzer B, Hennies HC (2016). Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations. Br J Dermatol. In press
  • Ludwig KU, Böhmer AC, Bowes J, Nikolić M, Ishorst N, Wyatt N, Hammond NL, Gölz L, Thieme F, Barth S, Schuenke H, Klamt J, Spielmann M, Aldhorae K, Rojas-Martinez A, Nöthen MM, Rada-Iglesias A, Dixon MJ, Knapp M, Mangold E (2017). Imputation of Orofacial Clefting Data Identifies Novel Risk Loci and Sheds Light on the Genetic Background of Cleft Lip ± Cleft Palate and Cleft Palate Only. Hum Mol Genet. 2017 Jan 13. pii: ddx012. doi: 10.1093/hmg/ddx012. [Epub ahead of print]
  • Vehreschild JJ, Heussel CP, Groll AH, Vehreschild MJ, Silling G, Würthwein G, Brecht M, Cornely OA (2017). Serial assessment of pulmonary lesion volume by computed tomography allows survival prediction in invasive pulmonary aspergillosis. Eur Radiol. 2017 Jan 12. doi: 10.1007/s00330-016-4717-4. [Epub ahead of print]
  • Kauppila TE, Kauppila JH, Larsson NG (2017). Mammalian Mitochondria and Aging: An Update. Cell Metab. 2017 Jan 10;25(1):57-71
  • Jais A, Brüning JC (2017). Hypothalamic inflammation in obesity and metabolic disease. J Clin Invest. 2017 Jan 3;127(1):24-32. doi:10.1172/JCI88878
  • Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mitrücker HW, Rose-John S, Schmidt-Arras D (2017). IL-6 trans-signaling is essential for the development of hepatocellular carcinoma. Hepatology. 2017 Jan; 65(1):89-103
  • Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kuhne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F (2016). mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. J Am Soc Nephrol
  • Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich FT, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A (2017), Korn T. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2017 Jan;18(1):74-85

To top

2016

  • Klionsky DJ, et al (2016). Guidelines for the use and interpretation assays for monitoring autophagy. (3rd edition). Autophagy. DOI:10.1080/15548627.2015.1100356
  • Neidhardt G, Hauke J, Ramser J, Groß E, Gehrig A, Müller CR, Kahlert AK, Hackmann K, Honisch E, Niederacher D, Heilmann-Heimbach S, Franke A, Lieb W, Thiele H, Altmüller J, Nürnberg P, Klaschik K, Ernst C, Ditsch N, Jessen F, Ramirez A, Wappenschmidt B, Engel C, Rhiem K, Meindl A, Schmutzler RK, Hahnen E (2016). Association Between Loss-of-Function Mutations Within the FANCM Gene and Early-Onset Familial Breast Cancer. JAMA Oncology. doi: 10.1001/jamaoncol.2016.5592
  • Ahmad I, Baig SM, Abdulkareem AR, Hussain MS, Sur I., Toliat MR, Nürnberg G, Dalibor N, Moawia A, Waseem SS, Asif M, Hafsad SM, Khan MMA, Hassan I, Rehman S, Thiele H, Altmüller J, Noegel AA, Nürnberg P (2017). Genetic heterogeneity in Pakistani microcephaly families revisited. Clin Genet. doi: 10.1111/cge.12955
  • Nikolić M, Papantonis A, Rada-Iglesias A (2016). GARLIC: A Bioinformatic Toolkit for Etiologically Connecting Diseases and Cell Type-Specific Regulatory Maps. Hum Mol Genet. 2016 Dec 22. pii: ddw423. doi: 10.1093/hmg/ddw423. [Epub ahead of print]
  • Sukumaran SK, Stumpf M, Salamon S, Ahmad I, Bhattacharya K, Fischer S, Muller R, Altmuller J, Budde B, Thiele H, Tariq M, Malik NA, Nürnberg P, Baig SM, Hussain MS, Noegel AA (2016). CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Molecular Genetics and Genomics. doi: 10.1007/s00438-016-1277-x
  • Burgute BD, Peche VS, Müller R, Matthias J, Gaßen B, Eichinger L, Glöckner G, Noegel AA (2016). The C-terminal SynMuv/DdDUF 926 domain regulates the function of the N-terminal domain of DdNKAP. PLoS ONE. 11:e0168617
  • Haliloglu G, Becker K, Temucin C, Talim B, Kucuksahin N, Pergande M, Motameny S, Nürnberg P, Aydingoz U, Topaloglu H, Cirak S (2016). Recessive PIEZO2 stop mutation causes distal arthrogryposis with distal muscle weakness, scoliosis and proprioception defects. Journal of Human Genetics. doi: 10.1038/jhg.2016.153
  • Islam S, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M (2016). Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet. 2016 Oct 29. pii: ddw352. [Epub ahead of print]
  • Rehimi R, Nikolic M, Cruz-Molina S, Tebartz C, Frommolt P, Mahabir E, Clément-Ziza M, Rada-Iglesias A (2016). Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations. Cell Rep. 2016 Dec 13;17(11):3062-3076
  • Hausen AC, Ruud J, Jiang H, Hess S, Varbanov H, Kloppenburg P, Brüning JC (2016). Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity. Cell Rep. 2016 Dec 6;17(10):2512-2521. doi: 10.1016/j.celrep.2016.11.030
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  • Lilienthal N, Lohmann G, Crispatzu G, Vasyutina E, Zittrich S, Mayer P, Herling CD, Tur MK, Hallek M, Pfitzer G, Barth S, Herling M (2016). A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells. Mol Cancer Ther. 2016 May;15(5):971-84. doi: 10.1158/1535-7163.MCT-15-0685. Epub 2016 Jan 29
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  • Cramer P, Hallek M, Eichhorst B (2016). State-of-the-Art Treatment and Novel Agents in Chronic Lymphocytic Leukemia. Oncology research and treatment. 39, 25-32
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  • Moosa S, Obregon MG, Altmuller J, Thiele H, Nürnberg P, Fano V, Wollnik B (2016). Novel IFT122 Mutations in Three Argentinian Patients with Cranioectodermal Dysplasia: Expanding the Mutational Spectrum. Am J Med Genet A. 170, 1295-1301
  • Korenke GC, Eggert M, Thiele H, Nürnberg P, Sander T, Steinlein OK (2016). Nocturnal frontal lobe epilepsy caused by a mutation in the GATOR1 complex gene NPRL3. Epilepsia. 57, E60-E63
  • Lal D, Neubauer BA, Toliat MR, Altmuller J, Thiele H, Nürnberg P, Kamrath C, Schanzer A, Sander T, Hahn A, Nothnagel M (2016). Increased Probability of Co-Occurrence of Two Rare Diseases in Consanguineous Families and Resolution of a Complex Phenotype by Next Generation Sequencing. PLoS ONE. 11, e0146040
  • Afschar S, Toivonen JM, Hoffmann JM, Tain LS, Wieser D, Finlayson AJ, Driege Y, Alic N, Emran S, Stinn J, Froehlich J, Piper MD, Partridge L(2016). Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proc Natl Acad Sci U S A. 113, 1321-1326
  • Reale C, Iervolino A, Scudiero I, Ferravante A, D'Andrea LE, Mazzone P, Zotti T, Leonardi A, Roberto L, Zannini M, de Cristofaro T, Shanmugakonar M, Capasso G, Pasparakis M, Vito P, Stilo R (2016). NF-kappaB Essential Modulator (NEMO) Is Critical for Thyroid Function. J Biol Chem. 291: 5765-73
  • Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Hohne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Muller R-U, Kruger M, Benzing T (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. 25: 1328–1344
  • Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger HG, Quiros PM, López-Otín C, Rugarli EI, Langer T (2016). Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 212, 157-166. doi: 10.1083/jcb.201507022
  • MacVicar T, Langer T (2016). OPA1 processing in cell death and disease: the long and short of it. J Cell Sci. 129, 2297-2306. doi:10.1242/jcs.159186
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  • Schermer B, Benzing T (2016). Endothelial cilia protect against atherosclerosis. EMBO Rep. 17: 125–126
  • Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M (2016). FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. Jan 14529(7):216-220
  • Wendtner CM, Hallek M, Fraser GA, Michallet AS, Hillmen P, Durig J, Kalaycio M, Gribben JG, Stilgenbauer S, Buhler A, Kipps TJ, Purse B, Zhang J, De Bedout S, Mei J, Chanan-Khan A (2016). Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter double-blinded randomized phase II trial. Leuk Lymphoma. 57, 1291-1299
  • Stiefelhagen M, Gigel C, Vasyutina E, Möllmann M, Breuer A, Mayer P, Dürig J, Herling M (2016). Activity of the CD40 antagonistic antibody lucatumumab - insights from CLL-niche mimicking xenografts and fludarabine combinations. Leuk Lymphoma. 2016 Jan 12:1-4
  • Daud S, Kakar N, Goebel I, Hashmi AS, Yaqub T, Nurnberg G, Nürnberg P, Morris-Rosendahl DJ, Wasim M, Volk AE, Kubisch C, Ahmad J, Borck G (2016). Identification of two novel ALS2 mutations in infantile-onset ascending hereditary spastic paraplegia. Amyotroph Lat Scl Fr. 17, 260-265
  • Schmitz J, Evers N, Awazawa M, Nicholls HT, Brönneke HS, Dietrich A, Mauer J, Blüher M, Brüning JC (2016). Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Mol Met. Jan 11;5(5):328-339
  • Spielmann M, Kakar N, Tayebi N, Leettola C, Nurnberg G, Sowada N, Lupianez DG, Harabula I, Flottmann R, Horn D, Chan WL, Wittler L, Yilmaz R, Altmuller J, Thiele H, van Bokhoven H, Schwartz CE, Nürnberg P, Bowie JU, Ahmad J, Kubisch C, Mundlos S, Borck G (2016). Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. Genome Research. 26, 183-191
  • Schulz JN, Nuchel J, Niehoff A, Bloch W, Schonborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B (2016). COMP-assisted collagen secretion--a novel intracellular function required for fibrosis. J Cell Sci. 129, 706-716
  • Ammann S, Schulz A, Krageloh-Mann I, Dieckmann NM, Niethammer K, Fuchs S, Eckl KM, Plank R, Werner R, Altmuller J, Thiele H, Nürnberg P, Bank J, Strauss A, von Bernuth H, Zur Stadt U, Grieve S, Griffiths GM, Lehmberg K, Hennies HC, Ehl S (2016). Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome. Blood. 127, 997-1006
  • Jabbari K, Nürnberg P (2016). A genomic view on epilepsy and autism candidate genes. Genomics. 108, 31-36
  • Maaß T, Bayley CP, Mörgelin M, Lettmann S, Bonaldo P, Paulsson M, Baldock C, Wagener R (2016). Heterogeneity of collagen VI microfibrils: Structural analysis of non-collagenous regions. J Biol Chem. 291, 5247-5258
  • Respuela P, Nikolic P, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A (2016). Foxd3 promotes exit from naïve pluripotency through enhancer decommissioning and inhibits germline specification. Cell Stem Cell. 2016 Jan 7;18(1):118-133. PMID:26748758
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  • Weinhold M, Shimabukuro-Vornhagen A, Franke A, Theurich S, Wahl P, Hallek M, Schmidt A, Schinkothe T, Mester J, von Bergwelt-Baildon M, Bloch W (2016). Physical exercise modulates the homeostasis of human regulatory T cells. J Allergy Clin Immun. 137, 1607-1610 e1608
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  • Bartram MP, Habbig S, Pahmeyer C, Hohne M, Weber LT, Thiele H, Altmuller J, Kottoor N, Wenzel A, Krueger M, Schermer B, Benzing T, Rinschen MM, Beck BB (2016). Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS. Hum Mol Genet. 25: 1152–1164
  • Kuhlmann N, Wroblowski S, Scislowski L, Lammers M (2016). RhoGDIa acetylation at K127 and K141 affects binding toward nonprenylated RhoA. Biochemistry. 2, 304-312
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  • Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tuscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nürnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J, Nitsch R (2016). Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO Molecular Medicine. 8, 25-38

2015

  • Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Baldus L, Scislowski L, Meyer-Teschendorf K, Zienert AY, Praefcke GJK, Nolte H, Krüger M, Schacherl M, Baumann U,  James LC, Chin JW, Lammers M (2016). Structural and mechanistic insights into the regulation of the Rho-regulator RhoGDIa by lysine acetylation. J Biol Chem. 291, 5484-5499
  • Koehler P, Cornely OA (2016). Contemporary Strategies in the Prevention and Management of Fungal Infections. Infect Dis Clin North Am.30(1):265-75
  • Piaggio F, Kondylis V, Pastorino F, Di Paolo D, Perri P, Cossu I, Schorn F, Marinaccio C, Murgia D, Daga A, Raggi F, Loi M, Emionite L, Ognio E, Pasparakis M, Ribatti D, Ponzoni M, Brignole C (2016). A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects. J Control Release. 223: 165-77
  • Greer EL, Becker B, Antebi A, Shi Y (2016). Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Cell Res. 26(2): 229-38
  • van Vugt MATM, Reinhardt HC (2015). Editorial: Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets. Frontiers in Genetics. 2015 Dec 22, doi: 10.3389/fgene.2015.00355
  • Zhang R, Thiele H, Bartmann P, Hilger AC, Berg C, Herberg U, Klingmuller D, Nürnberg P, Ludwig M, Reutter H (2016). Whole-Exome Sequencing in Nine Monozygotic Discordant Twins. Twin Res Hum Genet. 19, 60-65
  • Hallmann K, Kudin AP, Zsurka G, Kornblum C, Reimann J, Stuve B, Waltz S, Hattingen E, Thiele H, Nürnberg P, Rub C, Voos W, Kopatz J, Neumann H, Kunz WS (2016). Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. Brain. 139, 338-345
  • Logan A, Pell VR, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, Smith RA, Murphy MP (2016). Assessing the mitochondrial membrane potential in cells and in vivo using targeted click chemistry and mass spectrometry. Cell Metab. 23, 1-7
  • Klecker T, Wemmer M, Haag M, Weig A, Böckler S, Langer T, Nunnari J, Westermann B (2015). Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast. Sci Rep. 5, 1-14. doi: 101038/srep/18344  
  • Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen CM, Wrana JL, Scita G, Dejana E (2015). The actin binding protein EPS8 associates to VE-cadherin and modulates YAP intracellular localization and signaling. J Cell Biol. 211: 1177-92
  • Zaki MS, Heller R, Thoenes M, Nurnberg G, Stern-Schneider G, Nürnberg P, Karnati S, Swan D, Fateen E, Nagel-Wolfrum K, Mostafa MI, Thiele H, Wolfrum U, Baumgart-Vogt E, Bolz HJ (2016). PEX6 is Expressed in Photoreceptor Cilia and Mutated in Deafblindness with Enamel Dysplasia and Microcephaly. Human Mutation. 37, 170-174
  • Liss B, Cornely OA, Hoffmann D, Dimitriou V, Wisplinghoff H (2016). 1,3-beta-d-Glucan contamination of common antimicrobials. J Antimicrob Chemother. 71(4):913-5
  • Maertens JA, Raad, II, Marr KA, Patterson TF, Kontoyiannis DP, Cornely OA, et al (2016). Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial. Lancet. 387(10020):760-9
  • Horn S, Kirkegaard JS, Hoelper S, Seymour PA, Rescan C, Nielsen JH, Madsen OD, Jensen JN, Krüger M, Grønborg M, Ahnfelt-Rønne J (2016). Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo. Mol Endocrinol. 2016 Jan;30(1):133-43. doi: 10.1210/me.2015-1208. Epub 2015 Dec 9
  • Kelkar P, Walter A, Papadopoulos S, Mroß C, Munck M, Peche VS, Noegel AA (2015). Nesprin-2 mediated nuclear trafficking and its clinical implications. Nucleus. 6, 479- 489
  • Leipold E, Hanson-Kahn A, Frick M, Gong P, Bernstein JA, Voigt M, Katona I, Oliver Goral R, Altmuller J, Nürnberg P, Weis J, Hubner CA, Heinemann SH, Kurth I (2015). Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant. Nature Communications. 6, 10049
  • Moncunill-Massaguer C, Saura-Esteller J, Pérez-Perarnau A, Palmeri CM, Núñez-Vázquez S, Cosialls AM, González-Gironès DM, Pomares H, Korwitz A, Preciado S, Albericio F, Lavilla R, Pons G, Langer T, Iglesias-Serret D, Gil J (2015). A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. 6, 41750-41765. doi: 10.18632/oncotarget.6154
  • Kumar V, Bouameur JE, Bär J, Rice RH, Hornig‐Do HT, Roop D, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Wirth H, Seibel P, Magin T (2015). A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition and activity. J Cell Biol. 211:1057-1075
  • Rawstron AC, Fazi C, Agathangelidis A, Villamor N, Letestu R, Nomdedeu J, Palacio C, Stehlikova O, Kreuzer KA, Liptrot S, O'Brien D, de Tute RM, Marinov I, Hauwel M, Spacek M, Dobber J, Kater AP, Gambell P, Soosapilla A, Lozanski G, Brachtl G, Lin K, Boysen J, Hanson C, Jorgensen JL, Stetler-Stevenson M, Yuan C, Broome HE, Rassenti L, Craig F, Delgado J, Moreno C, Bosch F, Egle A, Doubek M, Pospisilova S, Mulligan S, Westerman D, Sanders CM, Emerson R, Robins HS, Kirsch I, Shanafelt T, Pettitt A, Kipps TJ, Wierda WG, Cymbalista F, Hallek M, Hillmen P, Montserrat E, Ghia P (2016). A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study. Leukemia. 30, 929-936
  • Yigit G, Wieczorek D, Bogershausen N, Beleggia F, Moller-Hartmann C, Altmuller J, Thiele H, Nürnberg P, Wollnik B (2016). A Syndrome of Microcephaly, Short Stature, Polysyndactyly, and Dental Anomalies Caused by a Homozygous KATNB1 Mutation. Am J Med Genet Part A. 170, 728-733
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  • Goede V, Fischer K, Engelke A, Schlag R, Lepretre S, Montero LF, Montillo M, Fegan C, Asikanius E, Humphrey K, Fingerle-Rowson G, Hallek M (2015). Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study. Leukemia. 29, 1602-1604
  • Kann M, Ettou S, Jung Y, Lenz M, Taglienti M, Park P, Schermer B, Benzing T, Kreidberg J (2015). Genome-Wide Analysis of Wilms’ Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 26: 2097–104
  • Steinmann J, Hamprecht A, Vehreschild MJ, Cornely OA, Buchheidt D, Spiess B, et al (2015). Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany. J Antimicrob Chemother. 70(5):1522-6
  • Cornely OA, Bohme A, Schmitt-Hoffmann A, Ullmann AJ (2015). Safety and pharmacokinetics of isavuconazole as antifungal prophylaxis in acute myeloid leukemia patients with neutropenia: results of a phase 2, dose escalation study. Antimicrobial agents and chemotherapy. 59(4):2078-85
  • Elsayed SM, Phillips JB, Heller R, Thoenes M, Elsobky E, Nurnberg G, Nürnberg P, Seland S, Ebermann I, Altmuller J, Thiele H, Toliat M, Korber F, Hu XJ, Wu YD, Zaki MS, Abdel-Salam G, Gleeson J, Boltshauser E, Westerfield M, Bolz HJ (2015). Non-manifesting AHI1 truncations indicate localized loss-of-function tolerance in a severe Mendelian disease gene. Hum Mol Genet. 24, 2594-2603
  • Khodakarami A, Saez I, Mels J, Vilchez D (2015). Mediation of organismal aging and somatic proteostasis by the germline. Frontiers in Molecular Biosciences. 2(3): 1-7
  • Rutsch F, MacDougall M, Lu C, Buers I, Mamaeva O, Nitschke Y, Rice GI, Erlandsen H, Kehl HG, Thiele H, Nürnberg P, Hohne W, Crow YJ, Feigenbaum A, Hennekam RC (2015). A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome. Am J Hum Genet. 96, 275-282
  • Mauer J, Denson JL, Brüning JC (2015). Versatile functions for IL-6 in metabolism and cancer. Trends Immunol. Feb;36(2):92-101
  • Marr KA, Schlamm HT, Herbrecht R, Rottinghaus ST, Bow EJ, Cornely OA, et al (2015). Combination antifungal therapy for invasive aspergillosis: a randomized trial. Ann Intern Med. 162(2):81-9
  • Spier I, Holzapfel S, Altmuller J, Zhao B, Horpaopan S, Vogt S, Chen S, Morak M, Raeder S, Kayser K, Stienen D, Adam R, Nürnberg P, Plotz G, Holinski-Feder E, Lifton RP, Thiele H, Hoffmann P, Steinke V, Aretz S (2015). Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas. Int J Cancer. 137, 320-331
  • Rinschen M, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maaß M, Bartram M, Lamkemeyer T, Schermer B, Benzing T, Brinkkoetter P (2015). Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics. 15: 1326–31
  • Hölper S, Nolte H, Bober E, Braun T, Krüger M (2015). Dissection of metabolic pathways in the Db/Db mouse model by integrative proteome and acetylome analysis. Molecular BioSystems. Mar;11(3):908-22
  • Hass J, Walton E, Wright C, Beyer A, Scholz M, Turner J, Liu J, Smolka MN, Roessner V, Sponheim SR, Gollub RL, Calhoun VD, Ehrlich S (2015). Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis. Prog Neuropsychopharmacol Biol Psychiatry. 59:31-9
  • Pasparakis M, Vandenabeele P (2015). Necroptosis and its role in inflammation. Nature. 517(7534):311-20
  • Castells-Roca L, Mueller M, Schumacher B (2015). Longevity through DNA damage tolerance. Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543
  • Hallek M, Kay NE, Osterborg A, Chanan-Khan AA, Mahler M, Salman M, Wan Y, Sun S, Zhuang SH, Howes A (2015). The HELIOS trial protocol: a phase III study of ibrutinib in combination with bendamustine and rituximab in relapsed/refractory chronic lymphocytic leukemia. Future Oncology. 11, 51-59
  • Chi JC, Roeper J, Schwarz G, Fischer-Schrader K (2015). Dual binding of 14-3-3 protein regulates Aabidopsis nitrate reductase activity. J Biol Inorg Chem. 20:277-86
  • Tennstaedt A, Aswendt M, Adamczak J, Collienne U, Selt M, Schneider G, Henn N, Schaefer C, Lagouge M, Wiedermann D, Kloppenburg P, Hoehn M (2015). Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks. Biomaterials. 2015 Mar;44:143-54. doi: 10.1016/j.biomaterials.2014.12.038
  • Coutelle O, Schiffmann LM, Liwschitz M, Brunold M, Goede V, Hallek M, Kashkar H, Hacker UT (2015). Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours. Br J Cancer.112, 495-503
  • Borck G, Hog F, Dentici ML, Tan PL, Sowada N, Medeira A, Gueneau L, Thiele H, Kousi M, Lepri F, Wenzeck L, Blumenthal I, Radicioni A, Schwarzenberg TL, Mandriani B, Fischetto R, Morris-Rosendahl DJ, Altmuller J, Reymond A, Nürnberg P, Merla G, Dallapiccola B, Katsanis N, Cramer P, Kubisch C (2015). BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies. Genome Research. 25, 155-166
  • Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schottle J, Ullrich RT, Altmuller J, Becker C, Nürnberg P, Seidel H, Bohm D, Goke F, Ansen S, Russell PA, Wright GM, Wainer Z, Solomon B, Petersen I, Clement JH, Sanger J, Brustugun OT, Helland A, Solberg S, Lund-Iversen M, Buettner R, Wolf J, Brambilla E, Vingron M, Perner S, Haas SA, Thomas RK (2015). Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biol. 16, 7
  • Saez I, Vilchez D (2015). Protein clearance mechanisms and their demise in age-related diseases. AIMS Molecular Science. 2(1): 1-21
  • Ermolaeva MA, Dakhovnik A, Schumacher B (2015). Quality control mechanisms in cellular and systemic DNA damage responses. Ageing Res Rev. 2015 Jan 2. pii: S1568-1637(14)00144-5. doi: 10.1016/j.arr.2014.12.009
  • Cornely OA, Meems L, Herbrecht R, Viscoli C, van Amsterdam RG, Ruhnke M (2015). Randomised, multicentre trial of micafungin vs. an institutional standard regimen for salvage treatment of invasive aspergillosis. Mycoses. 58(1):58-64

2014

  • Behringer K, Goergen H, Hitz F, Zijlstra JM, Greil R, Markova J, Sasse S, Fuchs M, Topp MS, Soekler M, Mathas S, Meissner J, Wilhelm M, Koch P, Lindemann HW, Schalk E, Semrau R, Kriz J, Vieler T, Bentz M, Lange E, Mahlberg R, Hassler A, Vogelhuber M, Hahn D, Mezger J, Krause SW, Skoetz N, Boll B, von Tresckow B, Diehl V, Hallek M, Borchmann P, Stein H, Eich H, Engert A, German Hodgkin Study G, Swiss Group for Clinical Cancer R, Arbeitsgemeinschaft Medikamentose T (2015). Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial. Lancet. 385, 1418-1427
  • Stader F, Wuerthwein G, Groll AH, Vehreschild JJ, Cornely OA, Hempel G (2015). Physiology-based pharmacokinetics of caspofungin for adults and paediatrics. Pharmaceutical research. 32(6):2029-37
  • Benzing T (2015). Polycystic kidney disease. HALTing PKD progression--revival of blood pressure control. Nat Rev Nephrol. 11: 129–31
  • Sousounis K, Bhavsar R, Looso M, Krüger M, Beebe J, Braun T, Tsonis AP (2015). Molecular signatures that correlate with induction of lens regeneration in newts: lessons from proteomic analysis. Human genomics. 8 (1), 22
  • Wang J, Krizowski S, Fischer K, Niks D, Tejero J, Sparacino-Watkins C, Wang L, Ragireddy P, Frizzell S, Kelley EE, Zhang Y, Basu P, Hille R, Schwarz G, Gladwin MT (2015). Sulfite oxidase catalyzes single electron transfer at molybdenum domain to reduce nitrite to nitric oxide. Antioxid Redox Signal. 2015 Aug 1;23(4):283-94. doi: 10.1089/ars.2013.5397
  • Chong AC, Vogt MC, Hill AS, Brüning JC, Zeltser LM (2014). Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness. Mol Metab. Dec 10;4(2):83-92
  • Hagmann H, Taniguchi Y, Pippin J, Kauerz H, Benzing T, Shankland S, Brinkkoetter P (2015). Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol. 308: C339-47
  • Seifert W, Kühnisch J, Maritzen T, Lommatzsch S, Hennies HC, Bachmann S, Horn D, Haucke V (2015). Cohen Syndrome-associated Protein COH1 Physically and Functionally Interacts with the Small GTPase RAB6 at the Golgi Complex and Directs Neurite Outgrowth. J Biol Chem.290:3349-58
  • Srivastava K, Hu J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG (2014). Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 26(6):880-95
  • Vilchez D, Saez I, Dillin A (2014). The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nature Communications. 5: 5659
  • Ehmke N, Caliebe A, Koenig R, Kant SG, Stark Z, Cormier-Daire V, Wieczorek D, Gillessen-Kaesbach G, Hoff K, Kawalia A, Thiele H, Altmüller J, Fischer-Zirnsak B, Knaus A, Zhu N, Heinrich V, Huber C, Harabula I, Spielmann M, Horn D, Kornak U, Hecht J, Krawitz PM, Nürnberg P, Siebert R, Manzke H, Mundlos S (2014). Homozygous and compound-heterozygous mutations in TGDS cause Catel-Manzke syndrome. Am J Hum Genet. 95, 763-770
  • Eming SA, Martin P, Tomic-Canic M (2014). Wound Repair and Regeneration: Mechanisms, signaling, and translation. Sci Transl Med. 6(265):265sr6
  • Mourier A, Matic S, Ruzzenente B, Larsson NG, Milenkovic D (2014). The Respiratory Chain Supercomplex Organization Is Independent of COX7a2l Isoforms. Cell Metab. Dec 2;20(6):1069-75
  • Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikea F (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. elife. 2014 Dec 2;3
  • Tellkamp F, Vorhagen S, Niessen CM (2014). Epidermal Polarity Genes in Health and Disease. Cold Spring Harbor Perspectives Med. 1;4(12):a015255. doi: 10.1101/cshperspect.a015255
  • Rada-Iglesias A (2014). Genetic variation within transcriptional regulatory elements and its implications for human disease. Biol Chem. 2014 Dec 1;395(12):1453-60. PMID:25205712
  • Walsh TJ, Skiada A, Cornely OA, Roilides E, Ibrahim A, Zaoutis T, et al (2014). Development of new strategies for early diagnosis of mucormycosis from bench to bedside. Mycoses. 2014;57 Suppl 3:2-7
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  • Clément-Ziza M, Marsellach FX, Codlin S, Papadakis MA, Reinhardt S, Rodríguez-López M, Martin S, Marguerat S, Schmidt A, Lee E Workman CT, Bähler J, Beyer A (2014). Natural genetic variation impacts expression levels of coding, non-coding, and antisense transcripts in fission yeast. Mol Syst Biol. 10:764
  • Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge LLarsson NG (2014). Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. Nucleic Acids Res. Dec 16;42(22):13920-38. Epub 2014 Nov 26
  • Mueller M, Castells-Roca L, Babu V, Ermolaeva M, Müller R, Frommolt P, Williams A, Greiss S, Schneider J, Benzing T, Schermer B, Schumacher B (2014). DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 16: 1168–79
  • Mueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B (2014). DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 2014 Dec;16(12):1168-79. doi: 10.1038/ncb3071. Epub 2014 Nov 24
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  • Haghighi A, Tiwari A, Piri N, Nürnberg G, Saleh-Gohari N, Neidhardt J, Nürnberg P, Berger W (2014). Homozygosity mapping and whole exome sequencing reveal a novel homozygous COL18A1 mutation causing Knobloch syndrome. PLoS ONE. 9, e112747
  • Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S (2014). Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 111(47):16836-41
  • Babu V, Hofmann K, Schumacher B (2014). A C. elegans homolog of the Cockayne syndrome complementation group A gene. DNA Repair. 2014 Dec:24:57-62. doi: 10.1016/j.dnarep.2014.09.012
  • Deckstein J, van Appeldorn J, Tsangarides M, Yiannakou K, Müller R, Stumpf M, Sukumaran SK, Eichinger L, Noegel AA, Riyahi TY (2015). The Dictyostelium discoideum GPHR ortholog is an ER and Golgi protein with roles during development. Eukaryot Cell. 14, 41-54
  • Huelsemann M, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker H, Theurich S, von Bergwelt-Baildon M, Pallasch C, Zahedi R, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel L (2015). Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia. 2015 Apr;29(4):981-4
  • Frumkin A, Dror S, Pokrzywa W, Bar-Lavan Y, Karady I, Hoppe T, Ben-Zvi A (2014). Challenging muscle homeostasis uncovers novel chaperone interactions in C. elegans. Front Mol Bio. 6, 1:21
  • Aguirre A, Montserrat N, Zacchigna S, Nivet E, Hishida T, Krause MN, Kurian L, Ocampo A, Vazquez-Ferrer E, Rodriguez-Esteban C, Kumar S, Moresco JJ, Yates JR, Campistol JM, Sancho-Martinez I, Giacca M, Izpisua Belmonte JC (2014). In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell. Nov 6;15(5):589-604
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  • Kloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R (2015). Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions. J Invest Dermatol. 135, 679-89
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  • Brown A, Tantcheva-Poor I, Eming SA (2014). Parallelen zwischen Wundheilung, chronisch entzündlichen Dermatosen und Neoplasien – Wissenswertes für die Praxis. Der Hautarzt. 65:934-43
  • Pulecio J, Nivet E, Sancho-Martinez I, Vitaloni M, Guenechea G, Xia Y, Kurian L, Dubova I, Bueren J, Laricchia-Robbio L, Izpisua Belmonte JC (2014). Conversion of human fibroblasts into monocyte-like progenitor cells. Stem Cells. Nov ;32(11):2923-38
  • Hallmann K, Zsurka G, Moskau-Hartmann S, Kirschner J, Korinthenberg R, Ruppert AK, Ozdemir O, Weber Y, Becker F, Lerche H, Elger CE, Thiele H, Nürnberg P, Sander T, Kunz WS (2014). A homozygous splice-site mutation in CARS2 is associated with progressive myoclonic epilepsy. Neurology. 83, 2183-2187
  • Bazzi H, Anderson KV (2014). Centrioles in the mouse: cilia and beyond. Cell Cycle. 13(18), 2809
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