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Publications 2015

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Adam Antebi

  • Antebi A (2015). Nuclear receptor signal transduction in C. elegans. WormBook : the online review of C elegans biology, 1-49
  • Denzel MS, Antebi A (2015). Hexosamine pathway and (ER) protein quality control. Curr Opin Cell Biol. 33, 14-18
  • Horikawa M, Sural S, Hsu AL, Antebi A (2015). Co-chaperone p23 regulates C. elegans Lifespan in Response to Temperature. PLoS Genetics. 11, e1005023
  • Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, et al. (2015). Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22

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Thomas Benzing

  • Bartram M, Dafinger C, Habbig S, Benzing T, Schermer B, Müller R (2015). Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation. BMC Nephrol. 16: 55
  • Benzing T (2015). Polycystic kidney disease. HALTing PKD progression--revival of blood pressure control. Nat Rev Nephrol. 11: 129–31
  • Brähler S, Ising C, Barrera Aranda B, Höhne M, Schermer B, Benzing T, Brinkkoetter P (2015). The NF-kB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-kB. Am J Physiol Renal Physiol. 309: F617-26
  • Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Gentileschi M, Germoni S, Monteleone V, Pellegrino M, Kann M, De Meo P, Pallocca M, Höpker K, Moretti F, Mattei E, Reinhardt H, Floridi A, Passananti C, Benzing T, Blandino G, Fanciulli M (2015). Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Cell Death Dis. 6: e1764
  • Ebner K, Feldkoetter M, Ariceta G, Bergmann C, Buettner R, Doyon A, Duzova A, Goebel H, Haffner D, Hero B, Hoppe B, Illig T, Jankauskiene A, Klopp N, König J, Litwin M, Mekahli D, Ranchin B, Sander A, Testa S, Weber L, Wicher D, Yuzbasioglu A, Zerres K, Dötsch J, Schaefer F, Liebau M, ESCAPE Study Group, GPN Study Group, Cachat F, Seeman T, Bruechle N, Querfeld U, Kirschstein M, Benz K, Buescher R, Latta K, Pohl M, Gross O, Patzer L, Kemper M, Pape L, Bernhardt W, Wuehl E, Beck B, Benzing T, Wygoda S, Wiemann D, Klaus G, Fehrenbach H, Wallot M, Lange-Sperandio B, Uetz B, Kranz B, Boeswald M, Staude H, Leichter H, Billing H, Beringer O, Ilmoja M, Lara L, Sallay P, Ardissino G, Emma F, Cerkauskiene R, Drozdz D, Niemirska A, Szczepanska M, Zaniew M, Paripovi D, Anarat A, Baskin E, Caliskan S, Candan C, Emre S, Dursun I, Ekinci Z, Delibas A, Kerecuk L, Guay-Woodford L (2015). Rationale, design and objectives of ARegPKD, a European ARPKD registry study. BMC Nephrol. 16: 22
  • Grahammer F, Benzing T, Huber T (2015). New insights into mechanisms of glomerular injury and repair from the 10th International Podocyte Conference 2014. Kidney Int. 87: 885–93
  • Hagmann H, Taniguchi Y, Pippin J, Kauerz H, Benzing T, Shankland S, Brinkkoetter P (2015). Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol. 308: C339-47
  • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris O, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning J, Brüning J, Kurschat C, Müller R, Wiesner R, Langer T, Benzing T, Brinkkoetter P (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 7: 275–87
  • Kann M, Ettou S, Jung Y, Lenz M, Taglienti M, Park P, Schermer B, Benzing T, Kreidberg J (2015). Genome-Wide Analysis of Wilms’ Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 26: 2097–104
  • Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, Taglienti M, Bordeianou L, Hartwig S, Rinschen M, Schermer B, Benzing T, Fan C, Kreidberg J (2015). WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 142: 1254–66
  • Rauen T, Eitner F, Fitzner C, Sommerer C, Zeier M, Otte B, Panzer U, Peters H, Benck U, Mertens P, Kuhlmann U, Witzke O, Gross O, Vielhauer V, Mann J, Hilgers R, Floege J, STOP-IgAN Investigators, Floege J, Eitner F, Rauen T, Moeller M, Michaelis A, Weihprecht H, Baatz E, Söllner S, Peters H, Budde K, Markmann D, Elitok S, Bieringer M, Schindler R, Frei U, Canaan-Kühl S, Erley C, Schlieps K, Kuhlmann U, Zandvoort F, Bodemann M, Hohenstein B, Hugo C, Palm C, Fleischer A, Hilgers K, Eckardt K, Jank S, Witzke O, Kirchmeyer R, Gross O, Müller G, Weber F, Birk H, Feustel A, Jeßen S, Stahl R, Panzer U, Kinzler E, Haller H, Bertram A, Bahlmann E, Zeier M, Sommerer C, Foellinger C, Wolf G, Busch M, Rüster C, Rath T, Ziefle S, Weik S, Benzing T, Bastek S, Kisner T, Mertens P, Bosselmann H, Piehler C, Westphalen S, Koepke S, Benck U, Göttmann U, Langhäuser B, Hoyer J, Maier T, Kortus-Goetze B, Vielhauer V, Fischereder M, Vilsmaier F, Sarkar O, Engelhardt S, Mann J, Stefanidou M, Otte B, Pavenstädt H, George B, Banas B, Böger A, Emmer T, Weiner S, Jochum E, Kiefer C, Heyne N, Artunc F, Georges G, Petermann A, Reichel H, Krumme B, Mettang T, Hirschberg M, Wanner C, Metzger T, Irmler-Mercier E (2015). Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 373: 2225–36
  • Rinschen MM, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maaß M, Bartram M, Lamkemeyer T, Schermer B, Benzing T, Brinkkoetter P (2015). Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics. 15: 1326–31
  • Rinschen MM, Benzing T, Limbutara K, Pisitkun T (2015). Proteomic analysis of the kidney filtration barrier-Problems and perspectives. Proteomics Clin Appl. 9: 1053–68
  • Seeger-Nukpezah T, Geynisman D, Nikonova A, Benzing T, Golemis E (2015). The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nat Rev Nephrol. 11: 515–34

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Matteo Bergami

  • Bergami M, Masserdotti G, Temprana S, Motori E, Eriksson TE, Göbel J, Yang SM, Conzelmann KK, Schinder AF, Götz M, Berninger B (2015). A critical period for experience-dependent remodelling of adult-born neuron connectivity. Neuron. 85, 710-717
  • Krzisch M, Temprana SG, Mongiat LL, Armida J, Schmutz V, Virtanen MA Kocher-Braissant J, Kraftsik R, Vutskits L, Conzelmann KK, Bergami M, Gage FH, Schinder AF, Toni N (2015). Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus. Brain Struct Funct. 220, 2027-2042

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Andreas Beyer

  • Eduati F, et. al. NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration (2015). Prediction of human population responses to toxic compounds by a collaborative competition. Nat. Biotechnol. doi:10.1038/nbt.3299
  • Gatto L, Hansen KD, Hoopman MR, Hermjakob H, Kohlbacher O, Beyer A (2015). Testing and validation of computational methods for mass spectrometry. J Prot. Res. DOI: 10.1021/acs.jproteome.5b00852
  • Hass J, Walton E, Wright C, Beyer A, Scholz M, Turner J, Liu J, Smolka MN, Roessner V, Sponheim SR, Gollub RL, Calhoun VD, Ehrlich S (2015). Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis. Prog Neuropsychopharmacol Biol Psychiatry. 59:31-9
  • Stephan J, Stegle O, Beyer A (2015). A Random Forest approach to capture genetic effects in the presence of population structure. Nat. Commun. 6:7432
  • Valenzano D, Beyer A, Johnson EA, Brunet A (2015). The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan. Cell. 163(6):1539-54

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Susanne Brodesser

  • Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H (2015). Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6. Cell Death Dis. 6:e1691
  • Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M (2015). Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling. J Invest Dermatol. 2015 Feb 23. doi: 10.1038/jid.2015.60. Epub 2015 Feb 23
  • Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Kühlbrandt W, Larsson N-G (2015). Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol. 208(4):429-42

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Jens Brüning

  • Chen Z, Zierath J, Kahn CR, Spiegelman BM, O’Rahilly S, Brüning JC (2015). How to stop the obesity epidemic. Cell. 161; 173-174
  • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. Feb 2;7(3):275-87
  • Knuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA (2015). Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation. J Immunol. Dec 1; 195(11): 5296-308
  • Mauer J, Denson JL, Brüning JC (2015). Versatile functions for IL-6 in metabolism and cancer. Trends Immunol. Feb;36(2):92-101
  • Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M (2015). Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling. J Invest Dermatol. Jun;135(6):1501-9
  • Ruud J, Brüning JC (2015). Light on leptin link to lipolysis. Nature Nov 5; 527(7576): 43-44
  • Sevgi M, Rigoux L, Kühn AB, Mauer J, Schilbach L, Hess ME, Gruendler TO, Ullsperger M, Stephan KE, Brüning JC, Tittgemeyer M (2015). An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning. J Neurosci. Sep 9;35(36):12584-92
  • Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC (2015). Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons. Cell. Sep 10;162(6):1404-17
  • Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Polić B (2015). NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015 Apr;16(4):376-85

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Oliver Cornely 

  • Bacher P, Jochheim-Richter A, Mockel-Tenbrink N, Kniemeyer O, Wingenfeld E, Alex R, et al (2015). Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer. Cytotherapy. 17(10):1396-405
  • Bacher P, Steinbach A, Kniemeyer O, Hamprecht A, Assenmacher M, Vehreschild MJ, et al (2015). Fungus-specific CD4(+) T cells for rapid identification of invasive pulmonary mold Infektion. Am J Respir Crit Care Med. 191(3):348-52
  • Boch T, Reinwald M, Postina P, Cornely OA, Vehreschild JJ, Heussel CP, et al (2015). Identification of invasive fungal diseases in immunocompromised patients by combining an Aspergillus specific PCR with a multifungal DNA-microarray from primary clinical samples. Mycoses. 58(12):735-45 
  • Bow EJ, Vanness DJ, Slavin M, Cordonnier C, Cornely OA, Marks DI, et al (2015). Systematic review and mixed treatment comparison meta-analysis of randomized clinical trials of primary oral antifungal prophylaxis in allogeneic hematopoietic cell transplant recipients. BMC Infect Dis. 15:128 
  • Cornely OA, Meems L, Herbrecht R, Viscoli C, van Amsterdam RG, Ruhnke M (2015). Randomised, multicentre trial of micafungin vs. an institutional standard regimen for salvage treatment of invasive aspergillosis. Mycoses. 58(1):58-64
  • Cornely OA, Gachot B, Akan H, Bassetti M, Uzun O, Kibbler C, et al (2015). Epidemiology and outcome of fungemia in a cancer Cohort of the Infectious Diseases Group (IDG) of the European Organization for Research and Treatment of Cancer (EORTC 65031). Clin Infect Dis. 61(3):324-31
  • Cornely OA, Bohme A, Schmitt-Hoffmann A, Ullmann AJ (2015). Safety and pharmacokinetics of isavuconazole as antifungal prophylaxis in acute myeloid leukemia patients with neutropenia: results of a phase 2, dose escalation study. Antimicrobial agents and chemotherapy. 59(4):2078-85
  • Fatkenheuer G, Cornely OA, Kern WV, Salzberger B, Stallmach A, Welte T (2015). Perspectives of infectious diseases in Germany. Dtsch Med Wochenschr.140(3):210-2
  • Glockner A, Cornely OA (2015). Candida glabrata - unique features and challenges in the clinical management of invasive infections. Mycoses. 58(8):445-50
  • Heimann SM, Vehreschild MJ, Cornely OA, Franke B, von Bergwelt-Baildon M, Wisplinghoff H, et al (2015). A cost and resource utilization analysis of micafungin bridging for hemato-oncological high-risk patients undergoing allogeneic stem cell transplantation. European journal of haematology. 94(6):526-31
  • Heimann SM, Vehreschild JJ, Cornely OA, Wisplinghoff H, Hallek M, Goldbrunner R, et al (2015). Economic burden of Clostridium difficile associated diarrhoea: a cost-of-illness study from a German tertiary care hospital. Infection. 43(6):707-14
  • Heimann SM, Cornely OA, Wisplinghoff H, Kochanek M, Stippel D, Padosch SA, et al (2015). Candidemia in the intensive care unit: analysis of direct treatment costs and clinical outcome in patients treated with echinocandins or fluconazole. Eur J Clin Microbiol Infect Dis. 34(2):331-8
  • Knitsch W, Vincent JL, Utzolino S, Francois B, Dinya T, Dimopoulos G, et al (2015). A Randomized, Placebo-controlled Trial of Preemptive Antifungal Therapy for the Prevention of Invasive Candidiasis Following Gastrointestinal Surgery for Intra-abdominal Infections. Clin Infect Dis. 61(11):1671-8
  • Louie T, Nord CE, Talbot GH, Wilcox M, Gerding DN, Buitrago M, et al (2015). Multicenter, Double- Blind, Randomized, Phase 2 Study Evaluating the Novel Antibiotic Cadazolid in Patients with Clostridium difficile Infection. Antimicrobial agents and chemotherapy. 59(10):6266-73
  • Marr KA, Schlamm HT, Herbrecht R, Rottinghaus ST, Bow EJ, Cornely OA, et al (2015). Combination antifungal therapy for invasive aspergillosis: a randomized trial. Ann Intern Med. 162(2):81-9
  • Mendling W, Friese K, Mylonas I, Weissenbacher ER, Brasch J, Schaller M, et al (2015). Vulvovaginal Candidosis (excluding chronic mucocutaneous candidosis). Guideline of the German Society of Gynecology and Obstetrics (AWMF Registry No. 015/072, S2k Level, December 2013). Geburtshilfe und Frauenheilkunde. 75(4):342-54
  • Mendling W, Brasch J, Cornely OA, Effendy I, Friese K, Ginter-Hanselmayer G, et al (2015). Guideline: vulvovaginal candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). Mycoses. 58 Suppl 1:1-15
  • Sandherr M, Hentrich M, von Lilienfeld-Toal M, Massenkeil G, Neumann S, Penack O, et al (2015). Antiviral prophylaxis in patients with solid tumours and haematological malignancies--update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). Ann Hematol. 94(9):1441-50
  • Stader F, Wuerthwein G, Groll AH, Vehreschild JJ, Cornely OA, Hempel G (2015). Physiology-based pharmacokinetics of caspofungin for adults and paediatrics. Pharmaceutical research. 32(6):2029-37
  • Steinmann J, Hamprecht A, Vehreschild MJ, Cornely OA, Buchheidt D, Spiess B, et al (2015). Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany. J Antimicrob Chemother. 70(5):1522-6
  • Tacke D, Wisplinghoff H, Kretzschmar A, Farowski F, Koehler P, Herweg J, et al (2015). First implementation of frozen, capsulized faecal microbiota transplantation for recurrent Clostridium difficile infection into clinical practice in Europe. Clin Microbiol Infect. 21(11):e82-4
  • Vehreschild MJ, Cornely OA (2015). Resistant fungi. Internist (Berl). 56(11):1271-6   
  • Verweij PE, Ananda-Rajah M, Andes D, Arendrup MC, Bruggemann RJ, Chowdhary A, et al (2015). International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 21-22:30-40

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Martin Denzel

  • Acevedo LM, Lindquist JN, Walsh BM, Sia P, Cimadamore F, Chen C, Denzel MS, Pernia CD, Ranscht B, Terskikh A, Snyder EY, Cheresh DA (2015). hESC Differentiation toward an Autonomic Neuronal Cell Fate Depends on Distinct Cues from the Co-Patterning Vasculature. Stem Cell Reports. May 20 S2213-6711(15)00125-3

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Sabine Eming

  • Ding X, Lucas T, Marcuzzi GP, Pfister H, Eming SA (2015). Distinct functions of epidermis- and myeloid cell-specific VEGF-A in human papillomavirus type 8-mediated tumorigenesis. Cancer Res. 75:330-43
  • Freudenberg U, Zieris A, Karolina Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C (2015). Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds. J Control Release. 220:79-88
  • Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Willenborg S, Krieg T, Sutherland T, Migge T, Richardson R, Hammerschmidt M, Allen JE, Eming SA (2015). IL-4Rα signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity. 43:803-16 
  • Knuever, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA (2015). Myeloid cell-restricted Insulin/IGF-1 receptor deficiency protects against skin inflammation. J Immunol. 195:5296-308
  • Kosmas K, Eskandarnaz A, Khosrandi A, Kumar A, Ranjan R, Eming SA, Noegel AA, Peche V (2015). CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds. Eur J Cell Biol. 94:32-45
  • Persa OD, Hunzelmann N, Poor I, Eming SA (2015). Unilateral linear papulosquamous rash in a healthy young man. J Dtsch Dermatol Ges. 13:1294-1297 (in press)

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Lukas P. Frenzel

  • Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP (2015). miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in chronic lymphocytic leukemia. Blood. Feb 10
  • Göckeritz E, Kerwien S, Baumann M, Wigger M, Vondey V, Neumann L, Landwehr T, Wendtner CM, Klein C, Liu N, Hallek M, Frenzel LP, Krause G (2015). Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells. Int J Cancer. Apr 24. Epub 2015 May 12
  • Holtick U, Frenzel LP, Shimabukuro-Vornhagen A, Theurich S, Claasen J, Scheid C, von Bergwelt-Baildon M, Fröhlich H, Wendtner CM, Chemnitz JM (2015). CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation. Ann Hematol. Jan;94(1):129-37
  • Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP (2015). Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia. Apr;29(4):981-4

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Michael Hallek

  • Behringer K, Goergen H, Hitz F, Zijlstra JM, Greil R, Markova J, Sasse S, Fuchs M, Topp MS, Soekler M, Mathas S, Meissner J, Wilhelm M, Koch P, Lindemann HW, Schalk E, Semrau R, Kriz J, Vieler T, Bentz M, Lange E, Mahlberg R, Hassler A, Vogelhuber M, Hahn D, Mezger J, Krause SW, Skoetz N, Boll B, von Tresckow B, Diehl V, Hallek M, Borchmann P, Stein H, Eich H, Engert A, German Hodgkin Study G, Swiss Group for Clinical Cancer R, Arbeitsgemeinschaft Medikamentose T (2015). Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial. Lancet. 385, 1418-1427
  • Berg V, Rusch M, Vartak N, Jungst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP (2015). miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL. Blood. 125, 2948-2957
  • Coutelle O, Schiffmann LM, Liwschitz M, Brunold M, Goede V, Hallek M, Kashkar H, Hacker UT (2015). Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours. Br J Cancer. 112, 495-503
  • Eichhorst B, Robak T, Montserrat E, Ghia P, Hillmen P, Hallek M, Buske C, Committee EG (2015). Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 26 Suppl 5, v78-v84
  • Engel LA, Wittig S, Bock F, Sauerbier L, Scheid C, Holtick U, Chemnitz JM, Hallek M, Cursiefen C, Steven P (2015). Meibography and meibomian gland measurements in ocular graft-versus-host disease. Bone marrow transplantation. 50, 961-967
  • George J, Lim JS, Jang SJ, Cun Y, Ozretic L, Kong G, Leenders F, Lu X, Fernandez-Cuesta L, Bosco G, Muller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Putzer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmuller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castanos-Velez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Kohler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansen S, Hallek M, Wolf J, Vingron M, Yatabe, Y, Travis WD, Nurnberg P, Reinhardt C, Perner S, Heukamp L, Buttner R, Haas SA, Brambilla E, Peifer M, Sage J Thomas RK (2015). Comprehensive genomic profiles of small cell lung cancer. Nature. 524, 47-53
  • Gockeritz E, Kerwien S, Baumann M, Wigger M, Vondey V, Neumann L, Landwehr T, Wendtner CM, Klein C, Liu N, Hallek M, Frenzel LP, Krause G (2015). Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells. International journal of cancer Journal international du cancer. 137, 2234-2242
  • Goede V, Hallek M (2015). Towards improved frontline treatment of CLL in the elderly. Lancet. 385, 1814-1815
  • Goede V, Eichhorst B, Fischer K, Wendtner CM, Hallek M (2015). Past, present and future role of chlorambucil in the treatment of chronic lymphocytic leukemia. Leuk Lymphoma. 56, 1585-1592
  • Goede V, Fischer K, Engelke A, Schlag R, Lepretre S, Montero LF, Montillo M, Fegan C, Asikanius E, Humphrey K, Fingerle-Rowson G, Hallek, M (2015). Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study. Leukemia. 29, 1602-1604
  • Hallek, M (2015). Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. American journal of hematology. 90, 446-460
  • Hallek, M, Kay NE, Osterborg A, Chanan-Khan AA, Mahler M, Salman M, Wan Y, Sun S, Zhuang SH, Howes A (2015). The HELIOS trial protocol: a phase III study of ibrutinib in combination with bendamustine and rituximab in relapsed/refractory chronic lymphocytic leukemia. Future oncology. 11, 51-59
  • Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel, LP (2015). Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia. 29, 981-984
  • Krause G, Baki I, Kerwien S, Knodgen E, Neumann, L, Gockeritz E, Landwehr T, Heider KH, Hallek M (2015). Cytotoxicity of the CD37 antibody BI 836826 against chronic lymphocytic leukaemia cells in combination with chemotherapeutic agents or PI3K inhibitors. Br J Haematol. 2016 Jun;173(5):791-4. doi: 10.1111/bjh.13635. Epub 2015 Aug 14
  • Kutsch N, Hallek M, Eichhorst B (2015). Emerging therapies for refractory chronic lymphocytic leukemia. Leuk Lymphoma. 56, 285-292
  • Lanasa MC, Andritsos L, Brown JR, Gabrilove J, Caligaris-Cappio F, Ghia P, Larson RA, Kipps TJ, Leblond V, Milligan DW, Janssens A, Johnson AJ, Heerema NA, Buhler A, Stilgenbauer S, Devin J, Hallek M, Byrd JC, Grever MR (2015). Final results of EFC6663: a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia. Leuk Res. 39, 495-500
  • Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, Bottcher S, Carter SL, Cibulskis K, Mertens D, Sougnez CL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, Dohner H, Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ (2015). Mutations driving CLL and their evolution in progression and relapse. Nature. 526, 525-530
  • Langerbeins P, Bahlo J, Rhein C, Cramer P, Pflug N, Fischer K, Stilgenbauer S, Kreuzer KA, Wendtner CM, Eichhorst B, Hallek M (2015). The CLL12 trial protocol: a placebo-controlled double-blind Phase III study of ibrutinib in the treatment of early-stage chronic lymphocytic leukemia patients with risk of early disease progression. Future oncology. 11, 1895-1903
  • Langerbeins P, Maurer C, Cramer P, Eichhorst B, Hallek, M (2015). Second cancers in chronic lymphocytic leukemia: growing importance in the era of improved treatment outcomes. Leuk Lymphoma. 56, 1575-1576
  • Prinz C, Vasyutina E, Lohmann G, Schrader A, Romanski S, Hirschhauser C, Mayer P, Frias C, Herling CD, Hallek M, Schmalz HG, Prokop A, Mougiakakos D, Herling M (2015). Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden. Molecular cancer. 14, 114
  • Vasyutina E, Boucas JM, Bloehdorn J, Aszyk C, Crispatzu G, Stiefelhagen M, Breuer A, Mayer P, Lengerke C, Dohner H, Beutner D, Rosenwald A, Stilgenbauer S, Hallek M, Benner A, Herling M (2015). The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL. Leukemia. 29, 2003-2014
  • Vollbrecht C, Mairinger FD, Koitzsch U, Peifer M, Koenig K, Heukamp LC, Crispatzu G, Wilden L, Kreuzer KA, Hallek M, Odenthal M, Herling CD, Buettner R (2015). Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing. PloS one. 10, e0129544
  • Zimmer P, Mierau A, Bloch W, Struder HK, Hulsdunker T, Schenk A, Fiebig L, Baumann FT, Hahn M, Reinart N, Hallek M, Elter T (2015). Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine. Leuk Lymphoma. 56, 347-352

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Matthias Hammerschmidt

  • Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA (2015). Interleukin-4 receptor alpha signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity. 43, 803-816
  • Leibold S, Hammerschmidt M (2015). Long-term hyperphagia and caloric restriction caused by low- or high-density husbandry have differential effects on zebrafish postembryonic development, somatic growth, fat accumulation and reproduction. PLoS One. 10, e0120776
  • Schwamb B, Pick R, Fernández SB, Völp K, Heering J, Dötsch V, Bösser S, Jung J, Beinoraviciute-Kellner R, Wesely J, Zörnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker RJ, Agaimy A, Söder S, Reid-Lombardo K, Kendrick ML, Bardsley MR, Hayashi Y, Asuzu DT, Syed SA, Ordog T, Zörnig M (2015). FAM96A is a novel pro-apoptoic tumor suppressor in gastrointestinal stromal tumors. Int J Cancer. 137, 1318-1329
  • Westcot SE, Hatzold J, Urban MD, Richetti SK, Skuster KJ, Harm RM, Lopez Cervera R, Umemoto N, McNulty MS, Clark KJ, Hammerschmidt M, Ekker SC (2015). Protein-Trap insertional mutagenesis uncovers new genes involved in zebrafish skin development, including a neuregulin 2a-based ErbB signaling pathway required during median fin fold morphogenesis. PLoS One. 10, e0130688

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Hans-Christian Hennies

  • Becker K, Tinschert S, Lienert A, Bleuler PE, Staub F, Meinel A, Rößler J, Wach W, Hoffmann R, Kühnel F, Damert HG, Nick HE, Spicher R, Lenze W, Langer M, Nürnberg P, Hennies HC (2015). The importance of genetic susceptibility in Dupuytren’s disease. Clin Genet. 87:483-487
  • Gruber R, Sugarman JL, Crumrine D, Hupe M, Mauldin EA, Thyssen JP, Hennies HC, Schmuth M, Elias PM (2015). Sebaceous gland, hair shaft, and epidermal barrier abnormalities in keratosis pilaris with and without filaggrin deficiency. Am J Pathol. 185:1012-1021
  • Gruber R, Börnchen C, Rose K, Daubmann A, Volksdorf T, Wladykowski E, Vidal-Y-Sy S, Peters EM, Danso M, Bouwstra JA, Hennies HC, Moll I, Schmuth M, Brandner JM (2015). Diverse Regulation of Claudin-1 and Claudin-4 in Atopic Dermatitis. Am J Pathol. 185:2777-2789
  • Hennies HC (2015). All is balanced: Inter-α-trypsin inhibitors as unseen extracellular matrix proteins in epidermal morphology and differentiation. Exp Dermatol. 24:661-662
  • Moosbrugger-Martinz V, Jalili A, Schossig AS, Jahn K, Zschocke J, Schmuth M, Stingl G, Hennies HC, Gruber R (2015). Epidermal barrier abnormalities in exfoliative ichthyosis with a novel homozygous loss-of-function mutation in CSTA. Br J Dermatol. 172:1628-1632
  • Seifert W, Kühnisch J, Maritzen T, Lommatzsch S, Hennies HC, Bachmann S, Horn D, Haucke V (2015). Cohen Syndrome-associated Protein COH1 Physically and Functionally Interacts with the Small GTPase RAB6 at the Golgi Complex and Directs Neurite Outgrowth. J Biol Chem. 290:3349-58
  • Witting M, Molina M, Obst K, Plank R, Eckl KM, Hennies HC, Calderón M, Frieß W, Hedtrich S (2015). Thermosensitive Dendritic Polyglycerol-Based Nanogels for Cutaneous Delivery of Biomacromolecules. Nanomedicine. 11:1179-1187

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Marco Herling

  • Dondorf S, Schrader A, Herling M (2015). Interleukin-2-inducible T-cell Kinase (ITK) Targeting by BMS-509744 does not affect cell viability in T-cell prolymphocytic leukemia (T-PLL). J Biol Chem. 2015 Apr 17;290(16):10568-9
  • Herling M, Vasyutina E (2015). Multi-level BCR signals toward CLL. Blood. 2015, Mar; 125(10):1510-12
  • Herling M (2015). Are we improving the outcome for patients with T-cell prolymphocytic leukemia by allogeneic stem cell transplantation? Eur J Haematol. 2015 Mar; 94(3):191-2
  • Herling M (2015). Primäre kutane Lymphome. In: Lehnert H. ed., DGIM Innere Medizin. Series: Springer Reference Medizin, pp 1-11, in German, online edition 06/2015, Springer ISBN: 978-3-642-54676-1
  • Mrotzek C, Felcht M, Sommer A, Schrader A, Klemke CD, Herling M, Schlaak M, Fabri M (2015). Vitamin D controls apoptosis and proliferation of cutaneous T cell lymphoma cells. Exp Dermatol. 2015 Oct;24(10):798-800
  • Prinz C, Vasyutina E, Lohmann G, Schrader A, Romanski S, Hirschhäuser C, Mayer P, Frias C, Herling CD, Hallek M, Schmalz HG, Prokop A, Mougiakakos D, Herling M (2015). Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden. Mol Cancer. 2015 Jun 4;14(1):114
  • Schrader A, Herling M (2015). t(12;14) in murine T-ALL does not correspond to inv(14)/t(14;14) in human T-PLL. E-Letter Blood. 2015 May 15 
  • Vasyutina E, Boucas JM, Bloehdorn J, Aszyk C, Crispatzu G, Stiefelhagen M, Breuer A, Mayer P, Lengerke C, Döhner H, Beutner D, Rosenwald A, Stilgenbauer S, Hallek M, Benner A, Herling M (2015). The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL. Leukemia. 2015 Oct;29(10):2003-14

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Thorsten Hoppe

  • Brinkmann K, Schell M, Hoppe T, Kashkar H (2015). Regulation of the DNA damage response by ubiquitin conjugation. Front. Genet. 6, 98
  • Franz A, Kevei É, Hoppe T (2015). Double-edged alliance: mitochondrial surveillance by the UPS and autophagy. Curr Opin Cell Biol. 4, 37:18-27

     

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Sandra Iden 

  • Mescher M, Iden S (2015). Par Proteins in Tumor Formation and Progression. Cell Polarity 2. Role in Development and Disease. Springer VIII. ISBN 978-3-319-14466-5. Book chapter
  • Refaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM (2015). Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines. Invest Ophthalmol Vis Sci. Aug 1;56(9):5691-5697
  • Schlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM (2015). A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice. Invest Ophthalmol Vis Sci. 56(10):5965-73
  • Tuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K (2015). JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nature Communications. 6:8128 

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    Hamid Kashkar

    • Brinkmann K, Schell M, Hoppe T, Kashkar H (2015). Regulation of the DNA Damage Response by Ubiquitin Conjugation. Front Genet. 6:98
    • Coutelle O, Schiffmann LM, Liwschitz M, Brunold M, Goede V, Hallek M, Kashkar H, Hacker UT (2015). Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalization without inducing empty basement membrane sleeves in xenograft tumors. Br J Cancer. 112:495-503  
    • Förster A, Grotha S, Seeger JM, Rabenhorst A, Gehring M, Raap U, Létard S, Dubreuil P, Kashkar H, Walczak H, Roers A, Hartmann K (2015). Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells. Allergy. 70:764-74
    • Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Fernziel LP (2015). Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia. 29:981-4   
    • Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H (2015). Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6. Cell Death Dis. 6:e1691
    • Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle P, Krönke M, Mauch C, Kashkar H (2015). IAP antagonization induces inflammatory destruction of vascular endothelium EMBO Rep. 16:719-727

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    Peter Kloppenburg

    • Fusca D, Schachtner J, Kloppenburg P (2015). Colocalization of allatotropin and tachykinin-related peptides with classical transmitters in physiologically distinct subtypes of olfactory local interneurons in the cockroach (Periplaneta americana). J Comp Neurol. 2015 Jul 1;523(10):1569-86. doi: 10.1002/cne.23757
    • Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC (2015). Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons. Cell. 2015 Sep 10;162(6):1404-17. doi: 10.1016/j.cell.2015.08.032
    • Tennstaedt A, Aswendt M, Adamczak J, Collienne U, Selt M, Schneider G, Henn N, Schaefer C, Lagouge M, Wiedermann D, Kloppenburg P, Hoehn M (2015). Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks. Biomaterials. 2015 Mar;44:143-54. doi: 10.1016/j.biomaterials.2014.12.038

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    Natalia Kononenko

    • Kaempf N, Kochlamazashvili G, Puchkov D, Maritzen T, Bajjalieh SM, Kononenko NL, Haucke V (2015). Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles. PNAS. 112:7297-302
    • Kononenko NL, Haucke V (2015). Molecular mechanisms of presynaptic membrane retrieval and synaptic vesicle reformation. Neuron. 85, 484-496

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    Thomas Krieg

    • Frances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C (2015). A role for Rac1 activity in malignant progression of sebaceous skin tumors. Oncogene. 34, 5505-5512
    • Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maal1 T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA (2015). lnterleukin-4 receptor a signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity. 43, 803-816
    • Krieg T [Prof. Dr. Gerd Klaus Steigleder on his 90th birthday] (2015). J Dtsch Dermatol Ges. 13, 178-179
    • Matucci-Cerinic M, Krieg T, Guillevin L, Schwierin B, Rosenberg D, Cornelisse P, Denton CP (2015). Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry. Ann Rheum Dis. Nov 26. pii: annrheumdis-2015-208121. doi: 1 0.1136/annrheumdis- 2015-208121. Epub 2015 Nov 26
    • Peters AS, Brunner G, Krieg T, Eckes B (2015). Cyclic mechanical strain induces TGFJ31-signalling in dermal fibroblasts embedded in a 3D collagen lattice. Arch Dermatol Res. 2015, 307, 191-197

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    Martin Krönke

    • Jakobshagen K, Ward B, Baschuk N, Huss S, Brunn A, Malecki M, Fiolka M, Rappl G, Corogeanu D, Karow U, Schiller P, Abken H, Heukamp LC, Deckert M, Krönke M, Utermöhlen O (2015). Endogenous Il10 alleviates the systemic antiviral cellular immune response and T cell-mediated immunopathology in select organs of acutely LCMV-infected mice. Am J Pathol. 3025-38
    • Klimka A, Michels L, Glowalla E, Tosetti B, Krönke M, Krut O (2015). Montanide ISA 71 VG is advantageous to Freund's adjuvant in immunization against S. aureus infection of mice. Scand J Immunol. 291-97
    • Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M (2015). Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling. J Invest Dermatol. 1501-09
    • Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H (2015). Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6. Cell Death Dis. 1691
    • Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle PA, Krönke M, Mauch C, Kashkar H (2015). IAP antagonization promotes inflammatory destruction of vascular endothelium. EMBO Rep. 719-27

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    Marcus Krüger

    • Al-Furoukh N, Ianni A, Nolte H, Hölper S, Krüger M, Wanrooij D, Braun T (2015). ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells. BBA - Molecular Cell Research accepted Manuscript. 2015 Oct;1853(10 Pt A):2580-91. doi: 10.1016/j.bbamcr.2015.06.016. Epub 2015 Jul 2
    • De Boor S, Knyphausen P, Kuhlmann N, Wroblowski S, Brenig J, Scislowski L, Baldus L, Nolte H, Krüger M, Lammers M (2015). Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation. PNAS. doi:10.1073/pnas.1505995112
    • Hölper S, Nolte H, Bober E, Braun T, Krüger M (2015). Dissection of metabolic pathways in the Db/Db mouse model by integrative proteome and acetylome analysis. Molecular BioSystems. Mar;11(3):908-22
    • Krishnan K, Nolte H, Sun T, Kaur H, Sreenivasan K, Looso M, Offermanns S, Krüger M, Swiercz J (2015). Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate. Nature Communications. Apr 7;6:6658
    • Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Zienert AY, Meyer-Teschendorf K, Praefcke GJ, Nolte H, Krüger M, Schacherl M, Baumann U, James LC, Chin JW, Lammers M (2015). Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation. J Biol Chem. 291(11): 5484-99
    • Mayer S, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L (2015). Adrenergic repression of the epigenetic reader MeCP2 facilitates cardiac adaptation in chronic heart failure. Circ Res. 2015 Sep 11;117(7):622-33
    • Nolte H, Hölper S, Housley MP, Islam S, Piller T, Konzer A, Stainier DYR, Braun T, Krüger M (2015). Dynamics of Fin Regeneration in Zebrafish Using a Pulsed SILAC Approach. Proteomics. Feb;15(4):739-51
    • Petersen HO, Höger SK, Looso M, Lengfeld T, Kuhn A, Warnken U, Nishimiya-Fujisawa C, Schnölzer M, Krüger M, Özbek S, Simakov O, Holstein TW (2015). A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration. Mol Biol Evol. 2015 Aug;32(8):1928-47
    • Rossi A, Kontarakis Z, Gerri C, Nolte H, Hölper S, Krüger M, Stainier DY (2015). Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 2015 13;524(7564):230-3
    • Schild M, Ruhs A, Beiter T, Zügel M, Hudemann J, Reimer A, Krumholz-Wagner I, Wagner C, Keller J, Eder K, Krüger K, Krüger M, Braun T, Nieß A, Steinacker J, Mooren FC (2015). Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals. J Proteomics. 2015 Jun 3;122:119-32
    • Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Krüger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G (2015). High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell Res. 2015 Jun 5. doi: 10.1038/cr.2015.67
    • Sousounis K, Bhavsar R, Looso M, Krüger M, Beebe J, Braun T, Tsonis AP (2015). Molecular signatures that correlate with induction of lens regeneration in newts: lessons from proteomic analysis. Human genomics. 8 (1), 22
    • Zhang T, Guenther S, Looso M, Künne K, Krüger M, Kim J, Zhou J, Braun T (2015). Functional analysis of the satellite cell proteome identifies Prmt5 as a crucial regulator of muscle stem cell expansion in adult mice. Nature Communications. Jun 1; 6:7140 

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    Leo Kurian

    • Kurian L, Aguirre A, Sancho-Martinez I, Benner C, Hishida T, Nguyen TB, Reddy P, Nivet E, Krause MN, Nelles DA, Esteban CR, Campistol JM, Yeo GW, Izpisua Belmonte JC (2015). Identification of Novel Long Noncoding RNAs Underlying Vertebrate Cardiovascular Development. Circulation. Apr 7;131(14):1278-902. 2
    • Rangaraju S, Solis GM, Thompson RC, Rafael AGLo, Kurian L, Encalada S, Niculescu AB, Salomon DR (2015). Suppression of Transcriptional Drift Extends C. elegans Lifespan by Postponing the Onset of Mortality. eLife. Dec 1;4:e08833 

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    Michael Lammers

    • Brenig J, de Boor S, Knyphausen P, Kuhlmann N, Wroblowski S, Baldus L, Scislowski L, Artz O, Trauschies P, Baumann U, Neundorf I, Lammers M (2015). Structural and biochemical basis ft he inhibitory effect of liprin-a3 on mDia1 function. J. Biol. Chem. 290, 14314–14327
    • de Boor S, Knyphausen P, Kuhlmann N, Wroblowski S, Brenig J, Scislowski L, Baldus L, Nolte H, Krüger M, Lammers M (2015). The small GTP-binding protein Ran is regulated by post-translational lysine acetylation. PNAS. 112, E3679–E3688
    • Knyphausen P, Kuhlmann N, de Boor S, Lammers M (2015). Lysine acetylation as a fundamental regulator of Ran function: Implications for signaling of proteins of the Ras-superfamily. Small GTPases. 6, 189-195

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    Thomas Langer

    • Bahat A, Perlberg S, Melamed-Book N, Isaac S, Eden A, Lauria I, Langer T, Orly J (2015). Transcriptional activation of LON gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR). Mol Cell Endocrinol. 408, 62-72. doi: 10.1016/j.mce.2015.02.022
    • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 7, 275-287. doi: 10.15252/emmm.201404916
    • Kehrein K, Schilling R, Möller-Hergt BV, Wurm CA, Jakobs S, Lamkemeyer T, Langer T, Ott M (2015). Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies. Cell Rep. 10, 843-853. doi: 10.1016/j.celrep.2015.01.012
    • Klecker T, Wemmer M, Haag M, Weig A, Böckler S, Langer T, Nunnari J, Westermann B (2015). Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast. Sci Rep. 5, 1-14. doi: 101038/srep/18344  
    • Mancini C, Orsi L, Guo Y, Li J, Chen Y, Wang F, Tian L, Liu X, Zhang J, Jiang H, Nmezi BS, Tatsuta T, Giorgio E, Di Gregorio E, Cavalieri S, Pozzi E, Mortara P, Caglio MM, Balducci A, Pinessi L, Langer T, Padiath QS, Hakonarson H, Zhang X, Brusco A (2015). An atypical form of AOA2 with myoclonus associated with mutations in SETX and AFG3L2. BMC Med Genet. 16, 1-7. doi: 10.1186/s12881-015-0159-0
    • Miliara X, Garnett JA, Tatsuta T, Abid Ali F, Baldie H, Pérez-Dorado I, Simpson P, Yague E, Langer T, Matthews S (2015). Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. EMBO Rep. 16, 824-835. doi: 10.15252/embr.201540229
    • Mitsopoulos P, Chang YH, Wai T, König T, Dunn SD, Langer T, Madrenas J (2015). Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function. Mol Cell Biol. 35, 1838-1847. doi: 10.1128/MCB.00047-15
    • Moncunill-Massaguer C, Saura-Esteller J, Pérez-Perarnau A, Palmeri CM, Núñez-Vázquez S, Cosialls AM, González-Gironès DM, Pomares H, Korwitz A, Preciado S, Albericio F, Lavilla R, Pons G, Langer T, Iglesias-Serret D, Gil J (2015). A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. 6, 41750-41765. doi: 10.18632/oncotarget.6154
    • Quirós P, Langer T, López-Otín C (2015). New roles for mitochondrial prote­ases in health, ageing and disease. Nature Rev Mol Cell Biol. 16, 345-359. doi: 10.1038/nrm3984
    • Wai T, García-Prieto J, Baker MJ, Merkwirth C, Benit P, Rustin P, Rupérez FJ, Barbas C, Ibañez B, Langer T (2015). Imbalanced OPA1 processing and mitochondrial fragmentation causes heart failure in mice. Science. 350, 1221-1233. doi: 10.1126/science.aad0116

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    Nils-Göran Larsson

    • Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG (2015). Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nat Commun. Nov 10;6:8808. doi: 10.1038/ncomms9808
    • Kukat C, Davies KM, Wurm CA, Spåhr H, Bonekamp NA, Kühl I, Joos F, Polosa PL, Park CB, Posse V, Falkenberg M, Jakobs S, Kühlbrandt W, Larsson NG (2015). Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid. Proc Natl Acad Sci U S A. Sep 8;112(36):11288-93. doi: 10.1073/pnas.1512131112
    • Lagouge M, Mourier A, Lee HJ, Spåhr H, Wai T, Kukat C, Silva Ramos E, Motori E, Busch JD, Siira S; German Mouse Clinic Consortium, Kremmer E, Filipovska A, Larsson NG (2015). SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation. PLoS Genet. Aug 6;11(8):e1005423. doi:10.1371/journal.pgen.1005423. eCollection 2015 Aug
    • Lee S, Rose S, Metodiev MD, Becker L, Vernaleken A, Klopstock T, Gailus-Durner V, Fuchs H, Hrabě De Angelis M, Douthwaite S, Larsson NG (2015). Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing. Hum Mol Genet. Dec 20;24(25):7286-94. doi: 10.1093/hmg/ddv427
    • Milenkovic D, Larsson NG (2015). Mic10 Oligomerization Pinches off Mitochondrial Cristae. Cell Metab. May 5;21(5):660-1
    • Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015). Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol. Feb 16;208(4):429-42

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    Ivan Matic

    • Palazzo L, Thomas B, Jemth AS, Colby T, Leidecker O, Feijs KL, Zaja R, Loseva O, Puigvert JC, Matic I, Helleday T, Ahel I (2015). Processing of protein ADP-ribosylation by Nudix hydrolases. Biochemical Journal. 2015 Jun
    • Rack JG, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I, Peleg AY, Leys D, Traven A, Ahel I (2015). Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens. Molecular Cell. 2015 Jul 16
    • Tammsalu T, Matic I, Jaffray EG, Ibrahim AF, Tatham MH, Hay RT (2015). Proteome-wide identification of SUMO modification sites by mass spectrometry. Nat Protoc. 2015 Sep;10(9):1374-88. doi: 10.1038/nprot.2015.095. Epub 2015 Aug 20

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    Roman-Ulrich Müller

    • Bartram MP, Dafinger C, Habbig S, Benzing T, Schermer B, Müller RU (2015). Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation. BMC Nephrol. April 2015
    • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. March 2015

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    Carmen Niessen

    • Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen CM, Wrana JL, Scita G, Dejana E (2015). The actin binding protein EPS8 associates to VE-cadherin and modulates YAP intracellular localization and signaling. J Cell Biol. 211: 1177-92
    • Hempel M, Schmitz A, Winkler S, Kucukoglu O, Brückner S, Niessen CM, Christ B (2015). Pathological implications of cadherin zonation in mouse liver. Cell Mol Life Sci. 72:2599-612
    • Knüver J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA (2015). Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation. J Immunol. pii: 1501237. Epub 2015 Oct 30
    • Peters F, Vorhagen S, Brodesser S, Jacobshagen K, Brüning JC, Niessen CM, Krönke M (2015). Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling. J Invest Dermatol. 135:1501-9

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    Angelika Noegel

    • Deckstein J, van Appeldorn J, Tsangarides M, Yiannakou K, Müller R, Stumpf M, Sukumaran SK, Eichinger L, Noegel AA, Riyahi TY (2015). The Dictyostelium discoideum GPHR ortholog is an ER and Golgi protein with roles during development. Eukaryot Cell. 14, 41-54
    • Kelkar P, Walter A, Papadopoulos S, Mroß C, Munck M, Peche VS, Noegel AA (2015). Nesprin-2 mediated nuclear trafficking and its clinical implications. Nucleus. 6, 479- 489
    • Kosmas K, Eskandarnaz A, Khorsandi AB, Kumar A, Ranjan R, Eming SA, Noegel AA, Peche VS (2015). CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells into and contraction of wounds. Eur J Cell Biol. 94, 32-45
    • Li P, Noegel AA (2015). Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export. Nucleic Acids Res. 43, 9874-9888
    • Luo D, Umbach A, Fajol A, Noegel AA, Laufer S, Lang F, Föller M (2015). Influence of Annexin 7 on insulin sensitivity of cellular glucose uptake. Pflügers Archiv - Eur J Physiol. 467, 641-649 
    • Ramalingam N, Franke C, Jaschinski E, Winterhoff M, Lu Y, Brühmann S, Junemann A, Meier H, Noegel AA, Weber I, Zhao H, Merkel R, Schleicher M, Faix J (2015). A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D-confinement. Nature Commun. 6, 8496
    • Roth H, Sammereier M, Trommler G, Noegel AA, Schleicher M, Müller-Taubenberger A (2015). Balanced cortical stiffness is important for efficient migration of Dictyostelium cells in confined environments. Biochem Biophys Res. 467, 730-735
    • Schaap P, Barrantes I, Minx P, Sasaki N, Anderson RW, Bénard M, Biggar KK, Buchler NE, Bundschuh R, Chen X, Fronick C, Fulton L, Golderer G, Jahn N, Knoop V, Landweber L, Maric C, Miller D, Noegel AA, Peace R, Pierron G, Sasaki T, Schallenberg-Rüdinger M, Schleicher M, Singh R, Spaller T, Storey KB, Suzuki T, Tomlinson C, Tyson JJ, Warren WC, Werner ER, Werner-Felmayer G, Wilson RK, Winckler T, Gott JM, Glöckner G, Marwan W (2015). The Physarum polycephalum genome reveals extensive use of prokaryotic two-component and metazoan-type tyrosine kinase signaling. Genome Biol Evol. 8, 109-125
    • Sukumaran SK, Blau-Wasser R, Rohlfs M, Gallinger C, Schleicher M, Noegel AA (2015). The centrosomal component CEP161 interacts with the Hippo signaling pathway. Cell Cycle. 14, 1024-1035
    • Swaminathan K, Stumpf M, Müller R, Horn AC, Schmidbauer J, Eichinger L, Müller-Taubenberger A, Faix J, Noegel AA (2015). Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins. Scientific Reports. 5, 14437  

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    Peter Nürnberg

    • Abdallah AT, Fischer M, Nürnberg P, Nothnagel M, Frommolt P (2015). CoNCoS: copy number estimation in cancer with controlled support. J Bioinf Comput Biol. 13, 1550027
    • Andres F, Romera-Branchat M, Martinez-Gallegos R, Patel V, Schneeberger K, Jang S, Altmuller J, Nürnberg P, Coupland G (2015). Floral Induction in Arabidopsis by FLOWERING LOCUS T Requires Direct Repression of BLADE-ON-PETIOLE Genes by the Homeodomain Protein PENNYWISE. Plant physiology. 169, 2187-2199
    • Balabanova Y, Nikolayevskyy V, Ignatyeva O, Kontsevaya I, Mironova S, Kovalyov A, Kritsky A, Rodionova Y, Fedorin I, Casali N, Hooper R, Horstmann RD, Nejentsev S, Hoffner S, Nürnberg P, Drobniewski F (2015). Beijing clades of Mycobacterium tuberculosis are associated with differential survival in HIV-negative Russian patients. Infect Genet Evol : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 36, 517-523
    • Becker K, Tinschert S, Lienert A, Bleuler PE, Staub F, Meinel A, Rossler J, Wach W, Hoffmann R, Kuhnel F, Damert HG, Nick HE, Spicher R, Lenze W, Langer M, Nürnberg P, Hennies HC (2015). The importance of genetic susceptibility in Dupuytren's disease. Clin Genet. 87, 483-487
    • Borck G, Hog F, Dentici ML, Tan PL, Sowada N, Medeira A, Gueneau L, Thiele H, Kousi M, Lepri F, Wenzeck L, Blumenthal I, Radicioni A, Schwarzenberg TL, Mandriani B, Fischetto R, Morris-Rosendahl DJ, Altmuller J, Reymond A, Nürnberg P, Merla G, Dallapiccola B, Katsanis N, Cramer P, Kubisch C (2015). BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies. Genome research. 25, 155-166
    • Boucas J, Fritz C, Schmitt A, Riabinska A, Thelen L, Peifer M, Leeser U, Nürnberg P, Altmueller J, Gaestel M, Dieterich C, Reinhardt HC (2015). Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. PLoS ONE. 10, e0125745
    • Budde BS, Mizumoto S, Kogawa R, Becker C, Altmuller J, Thiele H, Ruschendorf F, Toliat MR, Kaleschke G, Hammerle JM, Hohne W, Sugahara K, Nürnberg P, Kennerknecht I (2015). Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3. Hum Genet. 134, 691-704
    • Buyandelger B, Mansfield C, Kostin S, Choi O, Roberts AM, Ware JS, Mazzarotto F, Pesce F, Buchan R, Isaacson RL, Vouffo J, Gunkel S, Knoll G, McSweeney SJ, Wei H, Perrot A, Pfeiffer C, Toliat MR, Ilieva K, Krysztofinska E, Lopez-Olaneta MM, Gomez-Salinero JM, Schmidt A, Ng KE, Teucher N, Chen J, Teichmann M, Eilers M, Haverkamp W, Regitz-Zagrosek V, Hasenfuss G, Braun T, Pennell DJ, Gould I, Barton PJ, Lara-Pezzi E, Schafer S, Hubner N, Felkin LE, O'Regan DP, Brand T, Milting H, Nürnberg P, Schneider MD, Prasad S, Petretto E, Knoll R (2015). ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Circulation Cardiovascular genetics. 8, 643-652
    • Castori M, Pascolini G, Parisi V, Sana ME, Novelli A, Nürnberg P, Iascone M, Grammatico P (2015). Microcephaly, ectodermal dysplasia, multiple skeletal anomalies and distinctive facial appearance: delineation of cerebro-dermato-osseous-dysplasia. Am J Med Genet Part A. 167A, 842-851
    • Curtis J, Luo Y, Zenner HL, Cuchet-Lourenco D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S (2015). Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet. 47, 523-527
    • Elsayed SM, Phillips JB, Heller R, Thoenes M, Elsobky E, Nurnberg G, Nürnberg P, Seland S, Ebermann I, Altmuller J, Thiele H, Toliat M, Korber F, Hu XJ, Wu YD, Zaki MS, Abdel-Salam G, Gleeson J, Boltshauser E, Westerfield M, Bolz HJ (2015). Non-manifesting AHI1 truncations indicate localized loss-of-function tolerance in a severe Mendelian disease gene. Hum Mol Genet. 24, 2594-2603
    • Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schottle J, Ullrich RT, Altmuller J, Becker C, Nürnberg P, Seidel H, Bohm D, Goke F, Ansen S, Russell PA, Wright GM, Wainer Z, Solomon B, Petersen I, Clement JH, Sanger J, Brustugun OT, Helland A, Solberg S, Lund-Iversen M, Buettner R, Wolf J, Brambilla E, Vingron M, Perner S, Haas SA, Thomas RK (2015). Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biol. 16, 7
    • Galizia EC, Myers CT, Leu C, de Kovel CG, Afrikanova T, Cordero-Maldonado ML, Martins TG, Jacmin M, Drury S, Krishna Chinthapalli V, Muhle H, Pendziwiat M, Sander T, Ruppert AK, Moller RS, Thiele H, Krause R, Schubert J, Lehesjoki AE, Nürnberg P, Lerche H, Palotie A, Coppola A, Striano S, Gaudio LD, Boustred C, Schneider AL, Lench N, Jocic-Jakubi B, Covanis A, Capovilla G, Veggiotti P, Piccioli M, Parisi P, Cantonetti L, Sadleir LG, Mullen SA, Berkovic SF, Stephani U, Helbig I, Crawford AD, Esguerra CV, Kasteleijn-Nolst Trenite DG, Koeleman BP, Mefford HC, Scheffer IE, Sisodiya SM (2015). CHD2 variants are a risk factor for photosensitivity in epilepsy. Brain. 138, 1198-1207
    • Gardella E, Becker F, Moller RS, Schubert J, Lemke JR, Larsen LH, Eiberg H, Nothnagel M, Thiele H, Altmuller J, Syrbe S, Merkenschlager A, Bast T, Steinhoff B, Nürnberg P, Mang Y, Bakke Moller L, Gellert P, Heron S, Dibbens L, Weckhuysen S, Dahl HA, Biskup S, Tommerup N, Hjalgrim H, Lerche H, Beniczky S, Weber YG (2015). Benign infantile seizures and paroxysmal dyskinesia caused by an SCN8A mutation. Ann Neurol. 2016 Mar;79(3):428-36. doi: 10.1002/ana.24580. Epub 2016 Feb 13
    • George J, Lim JS, Jang SJ, Cun Y, Ozretic L, Kong G, Leenders F, Lu X, Fernandez-Cuesta L, Bosco G, Muller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Putzer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmuller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castanos-Velez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Kohler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansen S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Buttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK (2015). Comprehensive genomic profiles of small cell lung cancer. Nature. 524, 47-53
    • Gollasch B, Basmanav FB, Nanda A, Fritz G, Mahmoudi H, Thiele H, Wehner M, Wolf S, Altmuller J, Nürnberg P, Frank J, Betz RC (2015). Identification of a novel mutation in RIPK4 in a kindred with phenotypic features of Bartsocas-Papas and CHAND syndromes. Am J Med Genet Part A. 167A, 2555-2562
    • Groen JL, Andrade A, Ritz K, Jalalzadeh H, Haagmans M, Bradley TE, Jongejan A, Verbeek DS, Nürnberg P, Denome S, Hennekam RC, Lipscombe D, Baas F, Tijssen MA (2015). CACNA1B mutation is linked to unique myoclonus-dystonia syndrome. Hum Mol Genet. 24, 987-993
    • Hardies K, de Kovel CG, Weckhuysen S, Asselbergh B, Geuens T, Deconinck T, Azmi A, May P, Brilstra E, Becker F, Barisic N, Craiu D, Braun KP, Lal D, Thiele H, Schubert J, Weber Y, van 't Slot R, Nürnberg P, Balling R, Timmerman V, Lerche H, Maudsley S, Helbig I, Suls A, Koeleman BP, De Jonghe P (2015). Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia. Brain. 138, 3238-3250
    • Hedergott A, Volk AE, Herkenrath P, Thiele H, Fricke J, Altmuller J, Nürnberg P, Kubisch C, Neugebauer A (2015). Clinical and genetic findings in a family with NMNAT1-associated Leber congenital amaurosis: case report and review of the literature. Graef Arch Clin Exp Ophthal. 253, 2239-2246
    • Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, Schroter F, Nürnberg P, Kroll H, Makrantonaki E, Zouboulis CC, Adjaye J (2015). Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks. Bmc Genomics. 16, 433
    • Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, Schroter F, Nürnberg P, Kroll H, Makrantonaki E, Zouboulis CC, Adjaye J (2015). Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks. Bmc Genomics. 16, 84
    • Hubers A, Just W, Rosenbohm A, Muller K, Marroquin N, Goebel I, Hogel J, Thiele H, Altmuller J, Nürnberg P, Weishaupt JH, Kubisch C, Ludolph AC, Volk AE (2015). De novo FUS mutations are the most frequent genetic cause in early-onset German ALS patients. Neurobiology of aging. 36, 3117 e3111-3116
    • Kakar N, Ahmad J, Morris-Rosendahl DJ, Altmuller J, Friedrich K, Barbi G, Nürnberg P, Kubisch C, Dobyns WB, Borck G (2015). STIL mutation causes autosomal recessive microcephalic lobar holoprosencephaly. Hum Genet. 134, 45-51
    • Kawalia A, Motameny S, Wonczak S, Thiele H, Nieroda L, Jabbari K, Borowski S, Sinha V, Gunia W, Lang U, Achter V, Nürnberg P (2015). Leveraging the power of high performance computing for next generation sequencing data analysis: tricks and twists from a high throughput exome workflow. PLoS ONE. 10, e0126321
    • Konig K, Peifer M, Fassunke J, Ihle MA, Kunstlinger H, Heydt C, Stamm K, Ueckeroth F, Vollbrecht C, Bos M, Gardizi M, Scheffler M, Nogova L, Leenders F, Albus K, Meder L, Becker K, Florin A, Rommerscheidt-Fuss U, Altmuller J, Kloth M, Nürnberg P, Henkel T, Bikar SE, Sos ML, Geese WJ, Strauss L, Ko YD, Gerigk U, Odenthal M, Zander T, Wolf J, Merkelbach-Bruse S, Buettner R, Heukamp LC (2015). Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 10, 1049-1057
    • Kuechler A, Altmuller J, Nürnberg P, Kotthoff S, Kubisch C, Borck G (2015). Exome sequencing identifies a novel heterozygous TGFB3 mutation in a disorder overlapping with Marfan and Loeys-Dietz syndrome. Molecular and cellular probes. 29, 330-334
    • Lal D, Pernhorst K, Klein KM, Reif P, Tozzi R, Toliat MR, Winterer G, Neubauer B, Nürnberg P, Rosenow F, Becker F, Lerche H, Kunz WS, Kurki MI, Hoffmann P, Becker AJ, Perucca E, Zara F, Sander T, Weber YG (2015). Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy. Epilepsia. 56, e129-133
    • Lal D, Ruppert AK, Trucks H, Schulz H, de Kovel CG, Kasteleijn-Nolst Trenite D, Sonsma AC, Koeleman BP, Lindhout D, Weber YG, Lerche H, Kapser C, Schankin CJ, Kunz WS, Surges R, Elger CE, Gaus V, Schmitz B, Helbig I, Muhle H, Stephani U, Klein KM, Rosenow F, Neubauer BA, Reinthaler EM, Zimprich F, Feucht M, Moller RS, Hjalgrim H, De Jonghe P, Suls A, Lieb W, Franke A, Strauch K, Gieger C, Schurmann C, Schminke U, Nürnberg P, Sander T (2015). Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies. PLoS Genet. 11, e1005226
    • Lal D, Steinbrucker S, Schubert J, Sander T, Becker F, Weber Y, Lerche H, Thiele H, Krause R, Lehesjoki AE, Nürnberg P, Palotie A, Neubauer BA, Muhle H, Stephani U, Helbig I, Becker AJ, Schoch S, Hansen J, Dorn T, Hohl C, Luscher N, von Spiczak S, Lemke JR (2015). Investigation of GRIN2A in common epilepsy phenotypes. Epilepsy Res. 115, 95-99
    • Leipold E, Hanson-Kahn A, Frick M, Gong P, Bernstein JA, Voigt M, Katona I, Oliver Goral R, Altmuller J, Nürnberg P, Weis J, Hubner CA, Heinemann SH, Kurth I (2015). Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant. Nature communications. 6, 10049
    • Moosa S, Chung BH, Tung JY, Altmuller J, Thiele H, Nürnberg P, Netzer C, Nishimura G, Wollnik B (2015). Mutations in SEC24D cause autosomal recessive osteogenesis imperfecta. Clin Genet. 2015 Oct 14. doi: 10.1111/cge.12678
    • Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Kramer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmuller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Hofer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Buttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M (2015). Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature. 526, 700-704
    • Reichwagen A, Ziepert M, Kreuz M, Godtel-Armbrust U, Rixecker T, Poeschel V, Reza Toliat M, Nürnberg P, Tzvetkov M, Deng S, Trumper L, Hasenfuss G, Pfreundschuh M, Wojnowski L (2015). Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma. Pharmacogenomics. 16, 361-372
    • Reinthaler EM, Dejanovic B, Lal D, Semtner M, Merkler Y, Reinhold A, Pittrich DA, Hotzy C, Feucht M, Steinbock H, Gruber-Sedlmayr U, Ronen GM, Neophytou B, Geldner J, Haberlandt E, Muhle H, Ikram MA, van Duijn CM, Uitterlinden AG, Hofman A, Altmuller J, Kawalia A, Toliat MR, Nürnberg P, Lerche H, Nothnagel M, Thiele H, Sander T, Meier JC, Schwarz G, Neubauer BA, Zimprich F (2015). Rare variants in gamma-aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes. Ann Neurol. 77, 972-986
    • Rosin N, Elcioglu NH, Beleggia F, Isguven P, Altmuller J, Thiele H, Steindl K, Joset P, Rauch A, Nürnberg P, Wollnik B, Yigit G (2015). Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability. Hum Mol Genet. 24, 3708-3717
    • Rutsch F, MacDougall M, Lu C, Buers I, Mamaeva O, Nitschke Y, Rice GI, Erlandsen H, Kehl HG, Thiele H, Nürnberg P, Hohne W, Crow YJ, Feigenbaum A, Hennekam RC (2015). A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome. Am J Hum Genet. 96, 275-282
    • Schramm A, Koster J, Assenov Y, Althoff K, Peifer M, Mahlow E, Odersky A, Beisser D, Ernst C, Henssen AG, Stephan H, Schroder C, Heukamp L, Engesser A, Kahlert Y, Theissen J, Hero B, Roels F, Altmuller J, Nürnberg P, Astrahantseff K, Gloeckner C, De Preter K, Plass C, Lee S, Lode HN, Henrich KO, Gartlgruber M, Speleman F, Schmezer P, Westermann F, Rahmann S, Fischer M, Eggert A, Schulte JH (2015). Mutational dynamics between primary and relapse neuroblastomas. Nat Genet. 47, 872-877
    • Scicluna BP, Klein Klouwenberg PM, van Vught LA, Wiewel MA, Ong DS, Zwinderman AH, Franitza M, Toliat MR, Nürnberg P, Hoogendijk AJ, Horn J, Cremer OL, Schultz MJ, Bonten MJ, van der Poll T (2015). A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission. Am J Respir Crit Care Med. 192, 826-835
    • Spier I, Holzapfel S, Altmuller J, Zhao B, Horpaopan S, Vogt S, Chen S, Morak M, Raeder S, Kayser K, Stienen D, Adam R, Nürnberg P, Plotz G, Holinski-Feder E, Lifton RP, Thiele H, Hoffmann P, Steinke V, Aretz S (2015). Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas. Int J Cancer. 137, 320-331
    • Stephen LA, Tawamie H, Davis GM, Tebbe L, Nürnberg P, Nurnberg G, Thiele H, Thoenes M, Boltshauser E, Uebe S, Rompel O, Reis A, Ekici AB, McTeir L, Fraser AM, Hall EA, Mill P, Daudet N, Cross C, Wolfrum U, Jamra RA, Davey MG, Bolz HJ (2015). TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23). eLife. 4
    • Thoenes M, Zimmermann U, Ebermann I, Ptok M, Lewis MA, Thiele H, Morlot S, Hess MM, Gal A, Eisenberger T, Bergmann C, Nurnberg G, Nürnberg P, Steel KP, Knipper M, Bolz HJ (2015). OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67). Orphanet J Rare Dis. 10, 15
    • Yigit G, Brown KE, Kayserili H, Pohl E, Caliebe A, Zahnleiter D, Rosser E, Bogershausen N, Uyguner ZO, Altunoglu U, Nurnberg G, Nürnberg P, Rauch A, Li Y, Thiel CT, Wollnik B (2015). Mutations in CDK5RAP2 cause Seckel syndrome. Molecular genetics & genomic medicine. 3, 467-480

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    Linda Partridge

    • Alice N, Partridge L (2015). Myc mouse and anti-ageing therapy. Trends Endocrinol Metab. 26, 163-164
    • Armanios M, de Cabo R, Mannick J, Partridge L, van Teuren J, Villeda S (2015). Translational strategies in aging and age-related disease. Nat Med. 21, 1395-1399
    • Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG (2015). Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nat Commun. 6, 8808
    • Burnouf S, Gorsky MK, Dols J, Grönke S, Partridge L (2015). Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo. Acta Neuropathol. 130, 35-47
    • Fontana L, Partridge L (2015). Promoting Health and Longevity through Diet: From Model Organisms to Humans. Cell. 161, 106-118
    • Hoffmann JM, Partridge L (2015). Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging. Crit Rev Biochem Mol Biol. 50, 380-392
    • Ivanov DK, Escott-Price V, Ziehm M, Magwire MM, Mackay TF, Partridge L, Thornton JM (2015). Longevity GWAS Using the Drosophila Genetic Reference Panel. J Gerontol A Biol Sci Med Sci. 70, 1470-1478
    • Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cocheme HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L (2015). Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain. 138, 1801-1816
    • Knuever J, Willenborg S, Ding X, Akyuz MD, Partridge L, Niesen CM, Brüning JC, Eming SA (2015). Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation. J Immunol. 195, 5296-5308
    • Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP (2015). Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster. Cell Rep. 11, 1856-1865
    • Partridge L (2015). Celebrating 350 years of Philosophical Transactions: life sciences papers. Philos Trans R Soc Lond B Biol Sci. 370, 20140380
    • Slack C, Alic N, Foley A, Cabecinha M, Hoddinott MP, Partridge L (2015). The Ras-Erk-ETS signalling pathway is a drug target for longevity. Cell. 162, 72-83
    • Ziehm M, Ivanov DK, Bhat A, Partridge L, Thornton JM (2015). SurvCurv database and online survival analysis platform update. Bioinformatics. 31, 3878-3880

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    Manolis Pasparakis

    • Eftychi C, Pasparakis M (2015). Epithelial IKKa licenses ILC3s to defend the intestinal barrier. J Exp Med. 212(10):1483                                                       
    • Koliaraki V, Pasparakis M, Kollias G (2015). IKKbeta in intestinal mesenchymal cells promotes initiation of colitis-associated cancer. J Exp Med. 212: 2235-51
    • Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M (2015). NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 28: 582-98
    • Kumari S, Pasparakis M (2015). Epithelial Cell Death and Inflammation in Skin. Curr Top Microbiol Immunol. 2015 Aug 15         
    • Pasparakis M, Vandenabeele P (2015). Necroptosis and its role in inflammation. Nature. 517(7534):311-20
    • Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand'Maison M, Papadopoulos P, Korpos E, Truchetet F, Rades D, Sorokin LM, Schmidt-Supprian M, Bedell BJ, Pasparakis M, Balschun D, D'Hooge R, Löscher W, Hamel E, Schwaninger M (2015). Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med. 212(10):1529-49
    • Tesio M, Tang Y, Müdder K, Saini M, von Paleske L, Macintyre E, Pasparakis M, Waisman A, Trumpp A (2015). Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway. J Exp Med. 212(4):525-38

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    Mats Paulsson

    • Becker AK, Mikolajek H, Werner JM, Paulsson M, Wagener R (2015). Characterization of recombinantly expressed matrilin VWA domains. Protein Expres Purif. 107, 20-28
    • Hintermann E, Bayer M, Pfeilschifter JM, Deak F, Kiss I, Paulsson M, Christen U (2015). Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution. Liver Int. 35, 1265-1273
    • Xin W, Heilig J, Paulsson M, Zaucke F (2015). Collagen II regulates chondrocyte integrin expression profile and differentiation. Connect Tissue Res. 56, 307-314

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    Hans Christian Reinhardt

    • Boucas J, Fritz C, Schmitt A, Riabinska A, Thelen L, Peifer M, Leeser U, Nuernberg P, Altmueller J, Gaestel M, Dieterich C, Reinhardt HC (2015). Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. PLoS ONE. 2015 May 20;10(5):e0125745
    • Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Gentileschi MP, Germoni S, Monteleone V, Pellegrino M, Kann M, De Meo PD, Pallocca M, Höpker K, Moretti F, Mattei E, Reinhardt HC, Floridi A, Passananti C, Benzing T, Blandino G, Fanciulli M (2015). Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Cell Death Dis. 2015 May 21;6:e1764
    • Dietlein F, Kalb B, Jokic M, Noll EM, Strong A, Tharun A, Ozretić L, Künstlinger H, Kambartel K, Randerath WJ, Jüngst C, Schmitt A, Torgovnick A, Richters A, Rauh D, Siedek F, Persigehl T, Mauch C, Bartkova J, Bradley A, Sprick MR, Trumpp A, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC (2015). A synergistic interaction between Chk1- and MK2 inhibitors in KRAS-mutant cancer. Cell. Jul 2;162(1):146-159
    • George J, Lim JS, Jang SJ, Cun Y, Ozretic L, Leenders F, Lu X, Fernandez-Cuesta L, Bosco G, Nguyen C, Berg J, Müller C, Dahmen I, Jahchan N, Yang D, Karnezis AN, Vaka D, Torres A, Menon R, Wang MS, Stuetz A, Korbel J, Wilkerson M, Hayes N, Engelmann D, Pützer B, Vlasic I, Seidel D, Pinther B, Schaub B, Becker C, Altmüller J, Yokota J, Khono T, Iwakawa R, Muley T, Peterson I, Chen Y, Soltermann A, Tischler V, Massion P, Zou Y, Wright GM, Russell P, Solomon B, Koch I, Field JK, Muscarella LA, La Torre A, Jakopovic M, Knezevic J, Heiden E, Roz L, Jovanovic D, Kontic M, Thunnissen E, Köhler J, Schuler M, Sanchez-Cespedes M, Salvesen H, Achter V, Bogus M, Schneider P, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt HC, Perner S, Heukamp LC , Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK (2015). Comprehensive genomic profiling of small cell lung cancer. Nature. 2015 Jul 13. doi: 10.1038/nature14664 Epub 2015 Jul 13
    • Huelsemann M, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker H, Theurich S, von Bergwelt-Baildon M, Pallasch C, Zahedi R, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel L (2015). Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia. 2015 Apr;29(4):981-4
    • Knittel G, Liedgens P, Reinhardt HC (2015). Targeting ATM-deficient CLL through interference with DNA repair pathways. Frontiers in Genetics. 2015 May 28, doi: 10.3389/fgene.2015.00207
    • van Vugt MATM, Reinhardt HC (2015). Editorial: Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets. Frontiers in Genetics. 2015 Dec 22, doi: 10.3389/fgene.2015.00355

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    Nirmal Robinson

    • Fischer J, Jung N, Robinson N, Lehmann C (2015). Sex differences in immune responses to infectious diseases. Infection. 2015 Aug;43(4):399-403

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    Elena Rugarli

    • Papadopoulos C, Orso G, Mancuso G, Herholz M, Gumeni S, Tadepalle N, Jungst C, Tzschichholz A, Schauss A, Honing S, Trifunovic A, Daga A, Rugarli E (2015). Spastin binds to lipid droplets and affects lipid metabolism. PLoS Genet. 11, e1005149
    • Rugarli E, Trifunovic A (2015). Is mitochondrial free radical theory of aging getting old? Biochim Biophys Acta. 1847:1345-6. doi: 10.1016/j.bbabio.2015.08.004

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    Bernhard Schermer

    • Bartram M, Dafinger C, Habbig S, Benzing T, Schermer B, Müller R (2015). Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation. BMC Nephrol. 16: 55
    • Brähler S, Ising C, Barrera Aranda B, Höhne M, Schermer B, Benzing T, Brinkkoetter P (2015). The NF-kB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-kB. Am J Physiol Renal Physiol. 309: F617-26
    • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris O, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning J, Brüning J, Kurschat C, Müller R, Wiesner R, Langer T, Benzing T, Brinkkoetter P (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 7: 275–87
    • Kann M, Ettou S, Jung Y, Lenz M, Taglienti M, Park P, Schermer B, Benzing T, Kreidberg J (2015). Genome-Wide Analysis of Wilms’ Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 26: 2097–104
    • Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, Taglienti M, Bordeianou L, Hartwig S, Rinschen M, Schermer B, Benzing T, Fan C, Kreidberg J (2015). WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 142: 1254–66
    • Rinschen M, Pahmeyer C, Pisitkun T, Schnell N, Wu X, Maaß M, Bartram M, Lamkemeyer T, Schermer B, Benzing T, Brinkkoetter P (2015). Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics. 15: 1326–31

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    Björn Schumacher

    • Castells-Roca L, Mueller M, Schumacher B (2015). Longevity through DNA damage tolerance. Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543
    • Edifizi D, Schumacher B (2015). Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Biomolecules. 2015, 5, 1855-1869; doi:10.3390/biom5031855
    • Ermolaeva MA, Dakhovnik A, Schumacher B (2015). Quality control mechanisms in cellular and systemic DNA damage responses. Ageing Res Rev. 2015 Jan 2. pii: S1568-1637(14)00144-5. doi: 10.1016/j.arr.2014.12.009
    • Frommolt P, Schumacher B (2015). Wormpath: searching for molecular interaction networks in Caenorhabditis elegans. Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015
    • Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H (2015). Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget. 2015 Oct 27;6(33):34106-17. doi: 10.18632/oncotarget.5896
    • Torgovnick A, Schumacher B (2015). DNA repair mechanisms in cancer development and therapy. Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157. eCollection 2015

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    Günter Schwarz

    • Arjune S, Schwarz G, Belaidi AA (2015). Involvement of the Cys-Tyr cofactor on iron binding in the active site of human cysteine dioxygenase. Amino Acids. 47:55-63
    • Belaidi AA, Röper J, Arjune S, Krizowski S, Trifunovic A, Schwarz G (2015). Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency. Biochem J. 2015 Jul 15;469(2):211-21. doi: 10.1042/BJ20140768
    • Chi JC, Roeper J, Schwarz G, Fischer-Schrader K (2015). Dual binding of 14-3-3 protein regulates Aabidopsis nitrate reductase activity. J Biol Inorg Chem. 20:277-86
    • Dejanovic B, Djémié T, Grünewald N, Suls A, Kress V, Hetsch F, Craiu D, Zemel M, Gormley P, Lal D; EuroEPINOMICS Dravet working group., Myers CT, Mefford HC, Palotie A, Helbig I, Meier JC, De Jonghe P, Weckhuysen S, Schwarz G (2015). Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy. EMBO Mol Med. 2015 Nov 27;7(12):1580-94. doi: 10.15252/emmm.201505323
    • Imhof T, Gruenewald N, Schwarz G, Noack MJ, Koch M (2015). Modified amelogenin is a new and versatile nanomaterial for biomedical applications. Biotechnol Bioeng. 2015 Aug;112(8):1708-13. doi: 10.1002/bit.25576
    • Reinthaler EM, Dejanovic B, Lal D, Semtner M, Merkler Y, Reinhold A, Pittrich DA, Hotzy C, Feucht M, Steinböck H, Gruber-Sedlmayr U, Ronen GM, Neophytou B, Geldner J, Haberlandt E, Muhle H, Ikram MA, van Duijn CM, Uitterlinden AG, Hofman A, Altmüller J, Kawalia A, Toliat MR; EuroEPINOMICS Consortium., Nürnberg P, Lerche H, Nothnagel M, Thiele H, Sander T, Meier JC, Schwarz G, Neubauer BA, Zimprich F (2015). Rare variants in γ-aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes. Ann Neurol. 2015 Jun;77(6):972-86. doi: 10.1002/ana.24395
    • Schwahn BC, van Spronsen JF, Belaidi AA, Bowhay S, Christodoulou J, Derks TG, Hennermann JB, Jameson E, König K, McGregor TL, Font-Montgomery E, Santamaria-Araujo JA, Santra S, Vaidya M, Vierzig A, Wassmer E, Weis I, Wong FY, Veldman A , Schwarz G (2015). Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: Observational prospective cohort study of the first 11 patients treated according to a standardised compassionate use treatment plan for up to five years. The Lancet. 2015 Nov 14;386(10007):1955-63. doi: 10.1016/S0140-6736(15)00124-5
    • Wang J, Krizowski S, Fischer K, Niks D, Tejero J, Sparacino-Watkins C, Wang L, Ragireddy P, Frizzell S, Kelley EE, Zhang Y, Basu P, Hille R, Schwarz G, Gladwin MT (2015). Sulfite oxidase catalyzes single electron transfer at molybdenum domain to reduce nitrite to nitric oxide. Antioxid Redox Signal. 2015 Aug 1;23(4):283-94. doi: 10.1089/ars.2013.5397
    • Winkelmann A, You X, Grünewald N, Häussler U, Krestel H, Haas CA, Schwarz G, Chen W, Meier JC (2015). Identification of a new genomic hot spot of evolutionary diversification of protein function. PLoS One. 2015 May 8;10(5):e0125413. doi: 10.1371/journal.pone.0125413

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    Philipp Steven

    • Dietrich-Ntoukas T, Steven P (2015). Ocular graft-versus-host disease. Ophthalmologe. 2015 Dec;112(12):1027-38; quiz 1039-40. doi:10.1007/s00347-015-0149-9
    • Eberwein P, Dietrich-Ntoukas T, Westekemper H, Cursiefen C, Steven P (2015). Patient-Centred Care of Ocular Graft-vs-Host Disease in Germany. Klin Monbl Augenheilkd. 2015 May;232(5):664-8. doi: 10.1055/s-0035-1545930. Epub 2015 May 19
    • Hos D, Steven P, Dietrich-Ntoukas T (2015). The situation of residents in ophthalmology in Germany: Results of an online survey. Ophthalmologe. 2015 Jun;112(6):498-503. doi: 10.1007/s00347-015-0030-x
    • Notara M, Refaian N, Braun G, Steven P, Bock F, Cursiefen C (2015). Short-term uvb-irradiation leads to putative limbal stem cell damage and niche cell-mediated upregulation of macrophage recruiting cytokines. Stem Cell Res. 2015 Nov;15(3):643-54. doi: 10.1016/j.scr.2015.10.008. Epub 2015 Oct 19
    • Siebelmann S, Steven P, Cursiefen C (2015). Intraoperative optical coherence tomography: ocular surgery on a higher level or just nice pictures? JAMA Ophthalmol. 2015 Oct;133(10):1133-4. doi:10.1001/jamaophthalmol.2015.2396
    • Siebelmann S, Hermann M, Dietlein T, Bachmann B, Steven P, Cursiefen C (2015). Intraoperative Optical Coherence Tomography in Children with Anterior Segment Anomalies. Ophthalmology. 2015 Dec;122(12):2582-4. doi:10.1016/j.ophtha.2015.06.004. Epub 2015 Jul 7
    • Siebelmann S, Jing B, Cursiefen C, Steven P (2015). Non-Invasive Diagnosis of Ocular Graft-versus-Host Disease. Klin Monbl Augenheilkd. 2015 May;232(5):652-7. doi: 10.1055/s-0035-1545830. Epub 2015 May 19
    • Steven P, Scherer D, Krösser S, Beckert M, Cursiefen C, Kaercher T (2015). Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease--A Prospective, Multicenter Noninterventional Study. J Ocul Pharmacol Ther. 2015 Oct;31(8):498-503. doi: 10.1089/jop.2015.0048. Epub 2015 Aug 21
    • Steven P, Sauerbier L, Siebelmann S, Gehlsen U, Tahmaz V, Wittig S, Scheid C, Cursiefen C (2015). Therapy for Ocular Graft-vs-Host Disease. Klin Monbl Augenheilkd. 2015 May;232(5):658-63. doi: 10.1055/s-0035-1545829. Epub 2015 May 19

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    Aleksandra Trifunovic

    • Belaidi AA, Röper J, Arjune S, Krizowski S, Trifunovic A, Schwarz G (2015). Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency. Biochem J. 2015 Jul 15;469(2):211-21. doi: 10.1042/BJ20140768
    • Papadopoulos C, Orso G, Mancuso G, Herholz M, Gumeni S, Tadepalle N, Jüngst C, Tzschichholz A, Schauss A, Höning S, Trifunovic A, Daga A, Rugarli EI (2015). Spastin binds to lipid droplets and affects lipid metabolism. PLoS Genet. 2015 Apr 13;11(4):e1005149. doi: 10.1371/journal.pgen.1005149
    • Rugarli E, Trifunovic A (2015). Is mitochondrial free radical theory of aging getting old? Biochim Biophys Acta. 2015 Nov;1847(11):1345-6. doi: 10.1016/j.bbabio.2015.08.004
    • Szczepanowska K, Trifunovic A (2015). Different faces of mitochondrial DNA mutators. Biochim Biophys Acta. 2015 Nov;1847(11):1362-72. doi: 10.1016/j.bbabio.2015.05.016

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    Mirka Uhlirova

      • Jindra M, Uhlirova M, Charles JP, Smykal V, Hill RJ (2015). Genetic Evidence for Function of the bHLH-PAS Protein Gce/Met as a Juvenile Hormone Receptor. PLoS Genetics. 11, e1005394  doi:10.1371/journal.pgen.1005394
      • Külshammer E, Mundorf J, Kilinc M, Frommolt P, Wagle P, Uhlirova M (2015). Interplay among transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy. Dis Model Mech. 8, 1279–1293 doi:10.1242/dmm.020719

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      Dario Valenzano

      • Cellerino A, Valenzano DR, Reichard M (2015). From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology. Biological Reviews. doi: 10.1111/brv.12183
      • Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A (2015). A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell. Feb 26;160(5):1013-26
      • Reichard M, Cellerino A, Valenzano DR (2015). Turquoise Killifish. Current Biology. Aug;25(17): R741-2. doi: 10.1016/j.cub.2015.05.009
      • Valenzano DR, Benayoun B, Singh PP, Zhang E, Etter PD, Hu CK, Clement-Ziza M, Willemsen D, Cui R, Harel I, Machado B, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A (2015).The African Turquoise Killifish genome provides insights into evolution and genetic architecture of lifespan. Cell. Dec 3;163(6):1539-54

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      David Vilchez

      • Khodakarami A, Saez I, Mels J, Vilchez D (2015). Mediation of organismal aging and somatic proteostasis by the germline. Frontiers in Molecular Biosciences. 2(3): 1-7
      • Koyuncu S, Irmak D, Saez I, Vilchez D (2015). Defining the general principles of stem cell aging: lessons from organismal models. Current Stem Cell Reports. 25(7): 162-169
      • Saez I, Vilchez D (2015). Protein clearance mechanisms and their demise in age-related diseases. AIMS Molecular Science. 2(1): 1-21

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      Sara Wickström

      • Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA (2015). Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun. 6:8198
      • Rahn E, Petermann P, Their K, Bloch W, Morgner J, Wickström SA, Knebel-Mörsdorf D (2015). Invasion of Herpes Simplex Virus Type 1 into Murine Epidermis: An Ex Vivo Infection Study, J Invest Dermatol.  135, 3009-3016
      • Schneider D, Wickström SA (2015). Force generation and transmission in keloid fibroblasts: Dissecting the role of mechanosensitive molecules in cell function. Exp Dermatol. 8, 574-575

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      Rudolf J. Wiesner

      • Baris OR, Ederer S, Neuhaus JFG, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck AC, Stöckigt F, Schrickel JW, Wiesner RJ (2015). Mosaic deficiency in mitochondrial oxidative metabolism promotes cardiac arrhythmia during aging. Cell Metabolism. 21, 667-77
      • Franko A, Hrabê de Angelis M, Wiesner RJ (2015).  Mitochondrial function, dysfunction and adaptation in the liver during the development of diabetes. In book: Mitochondria in Liver Disease. Chapter: Chapter 17, Publisher: CRC Press, Editors: Han D, Kaplowitz N, pp.383-411 (in press)
      • Huebbers CU, Adam AC, Preuss SF, Schiffer T, Schilder S, Guntinas-Lichius O, Schmidt M, Klussmann JP, Wiesner RJ (2015). High glucose uptake unexpectedly correlates with high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma. Oncotarget. 6, 36172-84
      • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 7, 275-287
      • Kloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R (2015). Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions. J Invest Dermatol. 135, 679-89
      • Kumar V, Bouameur JE, Bär J, Rice RH, HornigDo HT, Roop D, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Wirth H, Seibel P, Magin T (2015). A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition and activity. J Cell Biol. 211:1057-1075
      • Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H (2015). Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6. Cell Death Dis. 6: e1691    

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      Andreas Wodarz

      • Shahab J, Tiwari M, Honemann-Capito M, Krahn MP, Wodarz A (2015). Bazooka/PAR-3 is dispensable for polarity in Drosophila follicular epithelial cells. Biol Open. Mar 13;4(4):528-41. doi: 10.1242/bio.201410934
      • Tiwari M, Wodarz A (2015). Asymmetric cell division and the development of the central nervous system in Drosophila. Cell Polarity 2. Springer International Publishing, Klaus Ebnet (editor), 95-117

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      Thomas Wunderlich

      • Baris OR, Ederer S, Neuhaus JF, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck AC, Stöckigt F, Schrickel JW, Wiesner RJ (2015). Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging. Cell Metab. 2015 May 5;21(5):667-77
      • Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A (2015). Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms. Dis Model Mech. 2015 Apr;8(4):403-15
      • Rastetter RH, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, Hojeili S, Bhattacharya K, Wunderlich CM, Wunderlich FT, Odenthal M, Ziemann A, Eichinger L, Clemen CS (2015). Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer. 2015 Sep 15;15:638
      • Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Polić B (2015). NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015 Apr;16(4):376-85

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